Franken Margreet, Heintz Emelie, Gerber-Grote Andreas, Raftery James
Institute for Medical Technology Assessment, Erasmus University, Rotterdam, The Netherlands; Institute of Health Policy and Management, Erasmus University, Rotterdam, The Netherlands.
Health Outcomes and Economic Evaluation Research Group, Medical Management Centre, Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden.
Value Health. 2016 Dec;19(8):951-956. doi: 10.1016/j.jval.2016.08.001. Epub 2016 Sep 19.
A response to the challenge of high-cost treatments in health care has been economic evaluation. Cost-effectiveness analysis presented as cost per quality-adjusted life-years gained has been controversial, raising heated support and opposition.
To assess the impact of economic evaluation in decisions on what to fund in four European countries and discuss the implications of our findings.
We used a protocol to review the key features of the application of economic evaluation in reimbursement decision making in England, Germany, the Netherlands, and Sweden, reporting country-specific highlights.
Although the institutions and processes vary by country, health economic evaluation has had limited impact on restricting access of controversial high-cost drugs. Even in those countries that have gone the furthest, ways have been found to avoid refusing to fund high-cost drugs for particular diseases including cancer, multiple sclerosis, and orphan diseases. Economic evaluation may, however, have helped some countries to negotiate price reductions for some drugs. It has also extended to the discussion of clinical effectiveness to include cost.
The differences in approaches but similarities in outcomes suggest that health economic evaluation be viewed largely as rhetoric (in D.N. McCloskey's terms in The Rhetoric of Economics, 1985). This is not to imply that economics had no impact: rather that it usually contributed to the discourse in ways that differed by country. The reasons for this no doubt vary by perspective, from political science to ethics. Economic evaluation may have less to do with rationing or denial of medical treatments than to do with expanding the discourse used to discuss such issues.
医疗保健领域针对高成本治疗挑战的应对措施是进行经济评估。以每获得一个质量调整生命年的成本来表示的成本效益分析一直存在争议,引发了激烈的支持与反对。
评估经济评估对四个欧洲国家资金分配决策的影响,并讨论我们研究结果的意义。
我们使用了一个方案来审查经济评估在英国、德国、荷兰和瑞典报销决策中的应用关键特征,并报告各国的突出亮点。
尽管各国的机构和流程各不相同,但健康经济评估对限制有争议的高成本药物的获取影响有限。即使在那些走得最远的国家,也找到了避免拒绝为包括癌症、多发性硬化症和罕见病在内的特定疾病的高成本药物提供资金的方法。然而,经济评估可能有助于一些国家就某些药物的降价进行谈判。它还将讨论扩展到临床疗效,以纳入成本因素。
方法上的差异但结果上的相似表明,健康经济评估在很大程度上应被视为一种修辞(用D.N.麦克洛斯基在《经济学的修辞》[1985年]中的说法)。这并不意味着经济学没有影响:而是说它通常以各国不同的方式为讨论做出贡献。毫无疑问,从政治学到伦理学,不同视角下造成这种情况的原因各不相同。经济评估与医疗治疗的配给或拒绝可能关系不大,而与扩大用于讨论此类问题的话语有关。