Department of Post Graduate Studies and Research in Physics, Rani Durgawati University, Jabalpur, M.P. 482002, India.
Department of Physics, Global Engineering College, Jabalpur, M.P. 482001, India.
Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:982-993. doi: 10.1016/j.msec.2016.11.001. Epub 2016 Nov 4.
In the present work binary blends of polyvinyl alcohol (PVA) and chitosan (CS) were prepared by solution cast method and characterized by analytical methods like FTIR, XRD and SEM for seeking structural and morphological information. The blends were exposed to gamma radiation and evaluated for their improved mechanical strength. It was found that the tensile strength and microhardness increased after irradiation of CS-PVA films. Plastic effect due to absorption of water molecules and scissoring effect due to gamma irradiation were found to decrease the softness or increase the microhardness of the blends. Improved mechanical properties were attributed to intermolecular and intramolecular hydrogen bonds and adhesive nature of the blends also. The blends were also investigated for water intake behavior and in vitro blood compatibility property on the basis of certain in vitro tests like protein adsorption, haemolysis and blood clot formation on the un-irradiated and irradiated blend samples. The increased % swelling with time could be assigned to the fact that increasing water content facilitates the phase separation process within the blend which results in advancement in interstitial nano-void spaces which are occupied by water molecules. The blood compatibility results showed that when the amount of CS was varied from 0.5% to 2%, the amount of blood clot and percent haemolysis decreased while the protein adsorption increased with increasing CS content of the blend films.
本工作采用溶液浇铸法制备了聚乙烯醇（PVA）和壳聚糖（CS）的二元共混物，并通过傅里叶变换红外光谱（FTIR）、X 射线衍射（XRD）和扫描电子显微镜（SEM）等分析方法对其进行了表征，以寻求结构和形态信息。将共混物暴露于伽马辐射下，评估其机械强度的提高。结果发现，CS-PVA 薄膜经辐照后，拉伸强度和显微硬度均有所提高。由于水分子的吸收产生的塑性效应以及伽马辐照产生的剪切效应，降低了共混物的柔软性或提高了其显微硬度。共混物的机械性能得到改善归因于分子间和分子内氢键以及共混物的粘合性质。还根据某些体外测试，如未辐照和辐照共混样品上的蛋白质吸附、溶血和血栓形成，研究了共混物的吸水率行为和体外血液相容性。随时间增加的高 %溶胀可归因于以下事实：增加的含水量促进了共混物内的相分离过程，从而导致间质纳米空隙的扩展，这些空隙被水分子占据。血液相容性结果表明，当 CS 的量从 0.5%变化到 2%时，血栓形成量和溶血百分比降低，而随着共混物中 CS 含量的增加，蛋白质吸附增加。
