School of Pharmacy, Queen's University of Belfast, Belfast, Antrim, Northern Ireland, UK.
School of Pharmacy, Queen's University of Belfast, Belfast, Antrim, Northern Ireland, UK.
Carbohydr Polym. 2017 Feb 10;157:400-408. doi: 10.1016/j.carbpol.2016.09.066. Epub 2016 Sep 21.
This study describes the design/physicochemical properties of strontium-containing, mucoadhesive carbohydrate polymeric platforms, designed as treatments for dentine hypersensitivity. Interactive networks were composed of strontium chloride (10% w/w), one of two base polymers (sodium carboxymethylcellulose, NaCMC or hydroxyethylcellulose, HEC), polycarbophil (PC) and, when required, polyvinylpyrrolidone (PVP). The physicochemical properties were characterised using oscillatory and flow rheometry, texture profile analysis, mucoadhesion analysis and, additionally, the strontium release properties were examined. All platforms exhibited pseudoplastic flow. Increasing polymer concentrations increased network viscoelasticity, consistency, hardness, compressibility, gel strength, adhesiveness, mucoadhesion and, retarded strontium release. Principally zero-order strontium release was observed from all platforms. Incorporation of strontium reduced the network elasticity, consistency, hardness, compressibility, gel strength and mucoadhesion; HEC-based platforms being affected to a greater extent than NaCMC platforms. NaCMC-based platforms containing 10% strontium chloride, PVP (3% w/w) and PC (3% w/w) potentially displayed the correct balance of physicochemical properties for the treatment of dentine sensitivity.
本研究描述了含锶的、具有黏附性的碳水化合物聚合物平台的设计/物理化学性质，这些平台被设计为治疗牙本质敏感症的方法。交互网络由氯化锶（10%w/w）、两种基础聚合物（羧甲基纤维素钠或羟乙基纤维素）之一、聚卡波非和（当需要时）聚乙烯吡咯烷酮组成。使用振荡和流动流变学、质地分析、黏附性分析以及此外，还检查了锶释放特性来表征物理化学性质。所有平台均表现出假塑性流动。增加聚合物浓度会增加网络的粘弹性、稠度、硬度、可压缩性、凝胶强度、粘附性和黏附性，并延缓锶释放。所有平台主要表现出零级锶释放。锶的掺入降低了网络的弹性、稠度、硬度、可压缩性、凝胶强度和黏附性；HEC 基平台比 NaCMC 基平台受影响更大。含 10%氯化锶、3%w/w PVP 和 3%w/w PC 的 NaCMC 基平台可能表现出治疗牙本质敏感性的正确物理化学性质平衡。
