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退行性二尖瓣反流手术中晚期功能性三尖瓣反流的患病率

Prevalence of Late Functional Tricuspid Regurgitation in Degenerative Mitral Regurgitation Surgery.

作者信息

Vaturi Mordehay, Kotler Tali, Shapira Yaron, Weisenberg Daniel, Monakier Daniel, Sagie Alexander

机构信息

Rabin Medical Center, Beilinson Hospital, Petach-Tikva.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

出版信息

J Heart Valve Dis. 2016 Mar;25(2):157-161.

Abstract

BACKGROUND

Although significant late tricuspid regurgitation (TR) may develop after surgery for degenerative mitral regurgitation (MR), the use of routine tricuspid annuloplasty is debatable. The study aim was to determine the prevalence and predictors of significant late TR after surgery for degenerative MR.

METHODS

A total of 112 patients who had undergone surgery for degenerative MR without concomitant tricuspid valve repair (average follow up 7.7 ± 4.0 years) was studied retrospectively. The prevalence of post-surgical TR and predictors of progression were determined.

RESULTS

The majority of patients (97%) had non-significant TR (less than moderate) prior to surgery, although an overall trend of progression towards significant TR (grades 2 or 3) was noted in 17 patients (p = 0.0006). Of the 18 patients (16%) with late postoperative significant TR, only nine (8%) had severe TR with only a single referral to surgery. New-onset post-surgical atrial fibrillation was more common in patients who developed late significant TR (p = 0.002). Multivariate analysis of the pre-surgery variables, age >65 years and left ventricular dysfunction were shown to be independent predictors of late functional TR.

CONCLUSIONS

Significant progression in TR after surgery for degenerative MR was rare in this patient cohort. The impact of older age and left ventricular dysfunction at the time of surgery showed a strong association with post-surgical atrial fibrillation.

摘要

背景

尽管退行性二尖瓣反流(MR)手术后可能会出现严重的晚期三尖瓣反流(TR),但常规使用三尖瓣成形术仍存在争议。本研究的目的是确定退行性MR手术后严重晚期TR的发生率及预测因素。

方法

对112例接受退行性MR手术且未同期进行三尖瓣修复的患者(平均随访7.7±4.0年)进行回顾性研究。确定术后TR的发生率及病情进展的预测因素。

结果

大多数患者(97%)术前存在轻度TR(小于中度),不过17例患者出现了向严重TR(2级或3级)进展的总体趋势(p = 0.0006)。在18例(16%)术后晚期出现严重TR的患者中,只有9例(8%)出现严重TR,且仅1例接受了手术治疗。术后新发房颤在晚期出现严重TR的患者中更为常见(p = 0.002)。术前变量的多因素分析显示,年龄>65岁和左心室功能障碍是晚期功能性TR的独立预测因素。

结论

在该患者队列中,退行性MR手术后TR的显著进展较为罕见。手术时年龄较大和左心室功能障碍与术后房颤密切相关。

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