Lal Charitharth Vivek, Ambalavanan Namasivayam
Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, 176F Suite 9380, Women and Infants Center, 619 South 19th Street, Birmingham, AL 35249-7335, USA.
Early Hum Dev. 2017 Feb;105:35-39. doi: 10.1016/j.earlhumdev.2016.12.003. Epub 2016 Dec 15.
The pathogenesis of Bronchopulmonary Dysplasia (BPD) is multifactorial and the clinical phenotype of BPD is extremely variable. Predicting BPD is difficult, as it is a disease with a clinical operational definition but many clinical phenotypes and endotypes. Most biomarkers studied over the years have low predictive accuracy, and none are currently used in routine clinical care or shown to be useful for predicting longer-term respiratory outcome. Targeted cellular and humoral biomarkers and novel systems biology 'omic' based approaches including genomic and microbiomic analyses are described in this review.
支气管肺发育不良（BPD）的发病机制是多因素的，其临床表型极具变异性。预测BPD很困难，因为它是一种具有临床操作定义但有多种临床表型和内型的疾病。多年来研究的大多数生物标志物预测准确性较低，目前尚无一种用于常规临床护理或被证明对预测长期呼吸结局有用。本文综述了靶向细胞和体液生物标志物以及基于新型系统生物学“组学”的方法，包括基因组和微生物组分析。
