Reboani M C, Cirillo R, Franzone J S
Riv Eur Sci Med Farmacol. 1989 Apr;11(2):183-8.
The gastric tolerance of ferritin has been studied in Wistar rats and compared with a conventional antianaemic product (ferrous sulphate). The oral administration of the same amount of elementary iron (10-50-100 mg/kg 3 times in 24 h) from each compound produces different anatomopathological results. The treatment with ferritin caused only a moderate gastritic process. In contrast, the administration of ferrous sulphate induced a dose-dependent progression from incipient gastritis to intense gastritis, focal haemorrhagic gastritis and focal necrotizing gastritis. Ferritin did not produce other secondary effects, and is well tolerated even at the highest dosages.
已在Wistar大鼠中研究了铁蛋白的胃耐受性，并与传统抗贫血产品（硫酸亚铁）进行了比较。从每种化合物中口服等量的元素铁（10 - 50 - 100mg/kg，24小时内3次）会产生不同的解剖病理学结果。铁蛋白治疗仅引起中度胃炎过程。相比之下，硫酸亚铁的给药导致了从初期胃炎到严重胃炎、局灶性出血性胃炎和局灶性坏死性胃炎的剂量依赖性进展。铁蛋白未产生其他副作用，即使在最高剂量下也具有良好的耐受性。
