Malinovskaya Natalia A, Komleva Yulia K, Salmin Vladimir V, Morgun Andrey V, Shuvaev Anton N, Panina Yulia A, Boitsova Elizaveta B, Salmina Alla B
Research Institute of Molecular Medicine & Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky Krasnoyarsk, Russia.
Front Physiol. 2016 Dec 1;7:599. doi: 10.3389/fphys.2016.00599. eCollection 2016.
Currently, there is a considerable interest to the assessment of blood-brain barrier (BBB) development as a part of cerebral angiogenesis developmental program. Embryonic and adult angiogenesis in the brain is governed by the coordinated activity of endothelial progenitor cells, brain microvascular endothelial cells, and non-endothelial cells contributing to the establishment of the BBB (pericytes, astrocytes, neurons). Metabolic and functional plasticity of endothelial progenitor cells controls their timely recruitment, precise homing to the brain microvessels, and efficient support of brain angiogenesis. Deciphering endothelial progenitor cells physiology would provide novel engineering approaches to establish adequate microfluidically-supported BBB models and brain microphysiological systems for translational studies.
目前，作为脑血管生成发育程序的一部分，血脑屏障（BBB）发育的评估受到了广泛关注。脑内胚胎期和成体期的血管生成受内皮祖细胞、脑微血管内皮细胞以及对血脑屏障建立有贡献的非内皮细胞（周细胞、星形胶质细胞、神经元）的协同活动支配。内皮祖细胞的代谢和功能可塑性控制着它们的适时募集、精准归巢至脑微血管以及对脑血管生成的有效支持。解读内皮祖细胞生理学将为建立适用于转化研究的、由微流控技术支持的血脑屏障模型和脑微生理系统提供新的工程学方法。
