Gianfrancesco Milena A, Barcellos Lisa F
Division of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
J Neurol Neuromedicine. 2016;1(7):1-5. doi: 10.29245/2572.942x/2016/7.1064.
Several studies conducted around the world over the last decade have demonstrated that early childhood and adolescent obesity are significant risk factors for MS susceptibility. This association has been largely confirmed in females, while evidence supporting a strong role for obesity and risk of MS in males has been mixed. Further, interaction between increased body mass index and genetic as well as environmental factors in MS susceptibility has been proposed, and evidence of a causal relationship has recently been established. In this review, we discuss findings supporting the significant association between obesity and MS, as well as identify areas for future investigation.
在过去十年中，世界各地开展的多项研究表明，儿童期和青少年肥胖是多发性硬化症易感性的重要危险因素。这种关联在女性中已得到很大程度的证实，而支持肥胖在男性多发性硬化症风险中起重要作用的证据则好坏参半。此外，有人提出体重指数增加与多发性硬化症易感性中的遗传及环境因素之间存在相互作用，并且最近已经确立了因果关系的证据。在本综述中，我们讨论了支持肥胖与多发性硬化症之间显著关联的研究结果，并确定了未来的研究方向。
