多巴胺能药物无关性肌阵挛在特发性帕金森病中与震颤的相关性较小。

Dopaminergic medication unrelated myoclonus is less related to tremor in idiopathic Parkinson's disease.

作者信息

Sifoglu Ayla, Gunduz Aysegul, Kiziltan Gunes, Kiziltan Meral E

机构信息

Department of Neurology, Cerrahpaşa School of Medicine, Istanbul University, K.M.Pasa, 34098, Istanbul, Turkey.

出版信息

Neurol Sci. 2017 Apr;38(4):679-682. doi: 10.1007/s10072-016-2793-5. Epub 2016 Dec 18.

DOI:10.1007/s10072-016-2793-5

PMID:27990561

Abstract

Myoclonus in Parkinson's disease (PD) may be related or unrelated to dopaminergic medication and may share some features of cortical myoclonus. The aim of this study was to analyze clinical and electrophysiological correlates of the dopaminergic treatment unrelated myoclonus in PD patients. We included 17 PD patients with the end-of-dose myoclonus and 16 PD patients without myoclonus between January 2010 and June 2011. Surface electromyography of upper extremity muscles and long latency reflexes (LLRs) were performed. Positive or negative myoclonus with a duration of 35-100 ms was observed. Rest tremor was less frequent in the group with myoclonus. Only one PD patient with myoclonus had C reflex. Mean LLR amplitude was significantly high in PD with myoclonus compared to the group without myoclonus (p = 0.024). Dopaminergic treatment unrelated myoclonus is less related to rest tremor in PD, may be positive or negative, and exhibits similar features to cortical myoclonus.

摘要

帕金森病（PD）中的肌阵挛可能与多巴胺能药物有关或无关，并且可能具有一些皮质肌阵挛的特征。本研究的目的是分析帕金森病患者中与多巴胺能治疗无关的肌阵挛的临床和电生理相关性。我们纳入了2010年1月至2011年6月期间17例有剂末肌阵挛的帕金森病患者和16例无肌阵挛的帕金森病患者。对上肢肌肉进行表面肌电图检查并检测长潜伏期反射（LLRs）。观察到持续时间为35 - 100毫秒的正性或负性肌阵挛。肌阵挛组中静止性震颤的发生率较低。仅有1例有肌阵挛的帕金森病患者有C反射。与无肌阵挛组相比，有肌阵挛的帕金森病患者的平均长潜伏期反射振幅显著更高（p = 0.024）。与多巴胺能治疗无关的肌阵挛在帕金森病中与静止性震颤的相关性较小，可能为正性或负性，并且表现出与皮质肌阵挛相似的特征。