帕金森病及帕金森综合征的临床神经生理学
Clinical neurophysiology of Parkinson's disease and parkinsonism.
作者信息
Chen Robert, Berardelli Alfredo, Bhattacharya Amitabh, Bologna Matteo, Chen Kai-Hsiang Stanley, Fasano Alfonso, Helmich Rick C, Hutchison William D, Kamble Nitish, Kühn Andrea A, Macerollo Antonella, Neumann Wolf-Julian, Pal Pramod Kumar, Paparella Giulia, Suppa Antonio, Udupa Kaviraja
机构信息
Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada.
出版信息
Clin Neurophysiol Pract. 2022 Jun 30;7:201-227. doi: 10.1016/j.cnp.2022.06.002. eCollection 2022.
This review is part of the series on the clinical neurophysiology of movement disorders. It focuses on Parkinson's disease and parkinsonism. The topics covered include the pathophysiology of tremor, rigidity and bradykinesia, balance and gait disturbance and myoclonus in Parkinson's disease. The use of electroencephalography, electromyography, long latency reflexes, cutaneous silent period, studies of cortical excitability with single and paired transcranial magnetic stimulation, studies of plasticity, intraoperative microelectrode recordings and recording of local field potentials from deep brain stimulation, and electrocorticography are also reviewed. In addition to advancing knowledge of pathophysiology, neurophysiological studies can be useful in refining the diagnosis, localization of surgical targets, and help to develop novel therapies for Parkinson's disease.
本综述是运动障碍临床神经生理学系列的一部分。它聚焦于帕金森病和帕金森综合征。涵盖的主题包括帕金森病中震颤、僵硬、运动迟缓、平衡和步态障碍以及肌阵挛的病理生理学。还综述了脑电图、肌电图、长潜伏期反射、皮肤静息期、单脉冲和双脉冲经颅磁刺激对皮质兴奋性的研究、可塑性研究、术中微电极记录、深部脑刺激局部场电位记录以及皮质电图的应用。除了增进对病理生理学的认识外，神经生理学研究在完善诊断、确定手术靶点以及帮助开发帕金森病新疗法方面也可能有用。
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