Vieira Marcella Amaral Horta Barbosa, Saraiva Maria Isabel Ramos, Silva Larissa Karine Leite da, Fraga Rafael Cavanellas, Kakizaki Priscila, Valente Neusa Yuriko Sakai
MD (Graduate degree in Dermatology), Resident in Dermatology, São Paulo, SP, Brazil.
Resident in Dermatology, Hospital do Servidor Público Estadual (HSPE), São Paulo, SP, Brazil.
Rev Assoc Med Bras (1992). 2016 Nov;62(8):718-720. doi: 10.1590/1806-9282.62.08.718.
We report the case of a patient with rheumatoid arthritis who, after 2 months of treatment with etanercept, showed disseminated asymptomatic violaceous papules. Biopsy of the skin lesion showed chronic granulomatous dermatitis with negative staining for fungi and acid-fast bacilli (AFB). After discontinuation of etanercept, the patient's condition improved. Although apparently paradoxical, cases of cutaneous and systemic sarcoidosis after anti-TNF medications have been reported in the literature, with very few cases presenting exclusive cutaneous involvement.
我们报告了一例类风湿关节炎患者的病例,该患者在接受依那西普治疗2个月后,出现了散在的无症状紫罗兰色丘疹。皮肤病变活检显示为慢性肉芽肿性皮炎,真菌和抗酸杆菌(AFB)染色均为阴性。停用依那西普后,患者病情有所改善。尽管看似矛盾,但文献中已报道了抗TNF药物治疗后出现皮肤和系统性结节病的病例,仅有极少数病例表现为单纯皮肤受累。