Unterstell Natasha, Bressan Aline Lopes, Serpa Laura Araújo, Fonseca e Castro Pérola Peres da, Gripp Alexandre Carlos
Rio de Janeiro State University, Pedro Ernesto University Hospital, Dermatology Program, Rio de JaneiroRJ, Brazil.
Rio de Janeiro State University, Pedro Ernesto University Hospital, immunotherapy clinic, dermatology ward, Rio de JaneiroRJ, Brazil.
An Bras Dermatol. 2013 Nov-Dec;88(6 Suppl 1):197-9. doi: 10.1590/abd1806-4841.20132588.
The antagonists of tumor necrosis factor alpha (TNF-α) are increasingly being used in the treatment of inflammatory and autoimmune diseases. Several adverse effects of these drugs have been reported, including the paradoxical development of sarcoidosis, especially with the use of etanercept. We present the first Brazilian case report of systemic sarcoidosis induced by etanercept and a literature review.
肿瘤坏死因子α(TNF-α)拮抗剂越来越多地用于治疗炎症性和自身免疫性疾病。已报道了这些药物的几种不良反应,包括结节病的反常发展,尤其是在使用依那西普时。我们呈现了巴西首例依那西普诱发系统性结节病的病例报告及文献综述。