Eugênio Deise Santiago Girão, Souza Juliana A, Chojniak Rubens, Bitencourt Almir G V, Graziano Luciana, Souza Elvira F
Department of Diagnostic Imaging, A.C.Camargo Cancer Center, Fundação Antonio Prudente, São Paulo, SP, Brazil.
Rev Assoc Med Bras (1992). 2016 Nov;62(8):755-761. doi: 10.1590/1806-9282.62.08.755.
: To describe the clinical features, imaging findings and pathological aspects of breast cancer diagnosed in women under the age of 40 years.
: A retrospective, descriptive study was performed through analysis of medical records between November 2008 and August 2012. One hundred and twenty (120) patients were included, of whom 112 underwent mammography, 113 underwent ultrasonography, and 105 underwent magnetic resonance imaging (MRI). The histopathological data was obtained in most cases from post-surgical analysis, which was available for 113 patients.
: The mean age at diagnosis of primary breast cancer was 34 years. Only 11 patients (9.0%) had a family history of breast or ovarian cancer in first-degree relative. Ninety-two (92) patients sought medical attention after showing breast symptoms, and the presence of a palpable nodule was the main complaint. One hundred and twenty-two (122) primary tumors were diagnosed, of which 112 were invasive (95%). The most common histological type was invasive ductal carcinoma (73.8%). Luminal B was the predominant molecular subtype (42.6%). Ultrasonography was positive in 94.5% of the cases and the most common finding were nodules (94.8%). At mammography, the malignancy was observed in 92.8% and the presence of suggestive calcifications was the dominant feature. The MRI was positive in 98% of patients, and mass lesions were the most common.
: Most cases of breast cancer diagnosed in patients under the age of 40 years, in our population, had symptoms at diagnosis and tumor with more aggressive biological behavior. Despite the ultrasound has been the most widely used method, we found improved characterization of breast lesions when also used mammography and MRI.
描述40岁以下女性诊断为乳腺癌的临床特征、影像学表现及病理情况。
通过分析2008年11月至2012年8月期间的病历进行回顾性描述性研究。纳入120例患者，其中112例行乳腺钼靶检查，113例行超声检查，105例行磁共振成像（MRI）检查。大多数病例的组织病理学数据来自术后分析，113例患者有该数据。
原发性乳腺癌诊断时的平均年龄为34岁。仅有11例患者（9.0%）有一级亲属患乳腺癌或卵巢癌的家族史。92例患者在出现乳腺症状后就医，主要主诉为可触及结节。共诊断出122个原发性肿瘤，其中112个为浸润性（95%）。最常见的组织学类型是浸润性导管癌（73.8%）。管腔B型是主要的分子亚型（42.6%）。超声检查阳性率为94.5%，最常见表现为结节（94.8%）。乳腺钼靶检查时，恶性病变观察率为92.8%，主要特征为出现可疑钙化。MRI检查阳性率为98%，最常见表现为肿块病变。
在我们的研究人群中，40岁以下患者诊断出的大多数乳腺癌病例在诊断时有症状，且肿瘤具有更具侵袭性的生物学行为。尽管超声是最广泛使用的方法，但我们发现联合使用乳腺钼靶检查和MRI时，对乳腺病变的特征描述有所改善。
