Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.
Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Sci Rep. 2021 Oct 12;11(1):20205. doi: 10.1038/s41598-021-99600-6.
The purpose of this study is to investigate imaging characteristics of young age breast cancer (YABC) focusing on correlation with pathologic factors and association with disease recurrence. From January 2017 to December 2019, patients under 40 years old who were diagnosed as breast cancer were enrolled in this study. Morphologic analysis of tumor and multiple quantitative parameters were obtained from pre-treatment dynamic contrast enhanced breast magnetic resonance imaging (DCE-MRI). Tumor-stroma ratio (TSR), microvessel density (MVD) and endothelial Notch 1 (EC Notch 1) were investigated for correlation with imaging parameters. In addition, recurrence associated factors were assessed using both clinico-pathologic factors and imaging parameters. A total of 53 patients were enrolled. Several imaging parameters derived from apparent diffusion coefficient (ADC) histogram showed negative correlation with TSR; and there was negative correlation between MVD and Ve in perfusion analysis. There were nine cases of recurrences with median interval of 16 months. Triple negative subtype and low CD34 MVD positivity in Notch 1 hotspots showed significant association with tumor recurrence. Texture parameters reflecting tumor sphericity and homogeneity were also associated with disease recurrence. In conclusion, several quantitative MRI parameters can be used as imaging biomarkers for tumor microenvironment and can predict disease recurrence in YABC.
本研究旨在探讨年轻乳腺癌（YABC）的影像学特征，重点关注与病理因素的相关性及与疾病复发的关系。 2017 年 1 月至 2019 年 12 月，纳入了年龄小于 40 岁的乳腺癌患者。从术前动态对比增强乳腺磁共振成像（DCE-MRI）中获取肿瘤形态学分析和多个定量参数。研究肿瘤-间质比（TSR）、微血管密度（MVD）和内皮 Notch 1（EC Notch 1）与影像学参数的相关性。此外，还使用临床病理因素和影像学参数评估与复发相关的因素。共纳入 53 例患者。来自表观扩散系数（ADC）直方图的几个影像学参数与 TSR 呈负相关；灌注分析中 MVD 与 Ve 呈负相关。有 9 例复发，中位间隔为 16 个月。三阴性亚型和 Notch 1 热点中 CD34 MVD 阳性率低与肿瘤复发显著相关。反映肿瘤球形度和均匀性的纹理参数也与疾病复发相关。总之，几个定量 MRI 参数可用作肿瘤微环境的影像学标志物，并可预测 YABC 的疾病复发。
