聚阳离子大分子抑制兔输卵管中纤毛介导的卵子运输。
Polycationic macromolecules inhibit cilia-mediated ovum transport in the rabbit oviduct.
作者信息
Norwood J T, Hein C E, Halbert S A, Anderson R G
出版信息
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4413-6. doi: 10.1073/pnas.75.9.4413.
Abstract
In both in vitro and in vivo experiments, polycationic macromolecules,such as poly(L-lysine), inhibited the transport of either surrogate or freshly ovulated cumulus masses across the oviduct epithelial surface without affecting the ciliary beat. Whereas transport across the fimbria in vivo was completely inhibited, transport down the ampulla was 3 to 7 times slower than normal. The effects of these polycations suggest that cilia-mediated ovum transport may involve the formation of transient adhesive bonds between the tip of the cilium and elements of the cumulus mass during each beat cycle of the cilium.
摘要
在体外和体内实验中，聚阳离子大分子，如聚-L-赖氨酸，可抑制替代物或刚排卵的卵丘团块通过输卵管上皮表面的运输，而不影响纤毛摆动。虽然体内通过伞端的运输被完全抑制，但沿壶腹部向下的运输比正常情况慢3至7倍。这些聚阳离子的作用表明，纤毛介导的卵子运输可能涉及在纤毛的每个摆动周期中，纤毛尖端与卵丘团块成分之间形成短暂的粘附键。
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本文引用的文献
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