Tehrani Maryam Hajnorouzali, Akhlaghi Najmeh, Talebian Leila, Emami Jaber, Keyhani Siamak Etzad
Department of Pediatric Dentistry, Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pharmaceutics, Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Contemp Clin Dent. 2016 Oct-Dec;7(4):469-474. doi: 10.4103/0976-237X.194102.
The aim of the present study was to evaluate the effect of a probiotic drop containing , , and on salivary counts of (SM) and (LB) in children 3-6 years of age.
Sixty-one healthy children were randomly allocated into two parallel blocks in this double-blind, randomized controlled trial (IRCT2014120320202N1) from May to June 2015.
Finally 53 participants consumed five drops of placebo ( = 23) or probiotic ( = 30) every night for 2 weeks. Before intervention and 1 day after completion of the intervention, unstimulated salivary samples were collected, and microbiologic evaluations were carried out.
Data were analyzed with descriptive statistical methods Wilcoxon signed ranks, Mann-Whitney, and logistic regression.
SM level decreased significantly in probiotic group after intervention ( = 0.045), and there were significant differences in salivary SM counts after intervention between two groups ( = 0.04). In probiotic group, LB counts decreased significantly after intervention ( = 0.048); however, there were no significant differences between two groups ( = 0.216).
Use of this probiotic drop decreased salivary counts of SM; however, LB counts did not change. In addition, use of the drop in children with higher salivary counts appeared to be more effective.
本研究旨在评估含有嗜酸乳杆菌、双歧杆菌和嗜热链球菌的益生菌滴剂对3至6岁儿童唾液中变形链球菌（SM）和乳杆菌（LB）计数的影响。
在这项双盲随机对照试验（IRCT2014120320202N1）中，61名健康儿童于2015年5月至6月被随机分为两个平行组。
最终53名参与者每晚服用5滴安慰剂（n = 23）或益生菌（n = 30），持续2周。在干预前和干预完成后1天，收集未刺激的唾液样本并进行微生物学评估。
采用描述性统计方法、威尔科克森符号秩检验、曼 - 惠特尼检验和逻辑回归分析数据。
干预后益生菌组的SM水平显著下降（P = 0.045），两组干预后唾液SM计数存在显著差异（P = 0.04）。在益生菌组中，干预后LB计数显著下降（P = 0.048）；然而，两组之间无显著差异（P = 0.216）。
使用这种益生菌滴剂可降低唾液中SM的计数；然而，LB计数没有变化。此外，在唾液计数较高的儿童中使用该滴剂似乎更有效。
