Comparison of Antimicrobial Efficacy of Cinnamon Bark Oil Incorporated and Probiotic Blend Incorporated Mucoadhesive Patch against Salivary in Caries Active 7-10-year-old Children: An Study.

INTRODUCTION

Among the various plants studied, cinnamon has emerged as a potential herbal antimicrobial agent. Besides the medicinal plants, recently probiotics have also been recognized to affect cinnamon bark oil and other harmful oral and gut microflora.

AIM AND OBJECTIVE

This placebo-controlled study aims to compare the antimicrobial potential of cinnamon bark oil incorporated and probiotic blend [ (TSP-Lp1), and (TSP-Lrh1)] incorporated mucoadhesive patch against salivary in caries active 7-10-year-old children.

DESIGN

It was a double-blinded placebo-controlled study with = 60. They were randomly allotted into three groups-Group I: Cinnamon patch, group II: probiotic patch, and group III: control patch (placebo) with = 20 in each group.

MATERIALS AND METHODS

The study was carried out in three phases. In the first phase, the minimal inhibitory concentration (MIC) of cinnamon bark oil was determined against followed by the formulation of cinnamon and probiotic patches. After a washout period of 2 weeks and a collection of baseline saliva samples, these patches were tested on the subjects from respective groups for 14 days with twice a day placement protocol. On the 15th day, saliva samples were collected and cultured, CFU/mL of the saliva of for each subject was recorded and compared with baseline samples. Feedback in the form of a questionnaire was obtained from the patients.

STATISTICAL ANALYSIS

Descriptive statistics, paired -test for intragroup comparison, unpaired -test for intergroup comparison, analysis of variance (ANOVA) for intergroup comparison, and Scheffe's.

RESULTS

The results showed that both cinnamon patch and probiotic patch were comparable to each other in terms of their anti- activity. The intragroup comparison of the CFU/mL count showed a highly significant reduction from baseline to post-intervention for both the groups ( = 0.001).

CONCLUSION

Both cinnamon and probiotic blend have a strong antimicrobial property owing to their ability to cause significant reduction in salivary and both the patches showed good patient acceptance.

HOW TO CITE THIS ARTICLE

Gandhi HA, Srilatha KT, Deshmukh S, Comparison of Antimicrobial Efficacy of Cinnamon Bark Oil Incorporated and Probiotic Blend Incorporated Mucoadhesive Patch against Salivary in Caries Active 7-10-year-old Children: An Study. Int J Clin Pediatr Dent 2020;13(5):543-550.