Oxidant Status following Cardiac Surgery with Phosphorylcholine-Coated Extracorporeal Circulation Systems.

. Extracorporeal circulation (ECC) related systemic oxidative stress is a well-known entity but the underlying mechanisms are not clearly described. Our aim was to investigate the relation between the oxidative stress indices, inflammatory markers, and phosphorylcholine-coated (PCC) ECC systems. . Thirty-two consecutive coronary artery bypass grafting (CABG) cases were randomly assigned to Group I (PCC, = 18) and Group II (noncoated, = 14) ECC circuits. Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Tumor Necrosis Factor- (TNF-), Interleukin-1 (IL-), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-10 (IL-10), and Procalcitonin (PCT) levels were measured at 5 different time points. The association between the oxidative indices levels and PCC system used was analyzed. . In Group I TOS and TAS statuses were increased at 1, 2, 3, and 4, while IL-10 and TNF- levels accompanied those raises only at 2 (Group I-Group II, 4.73 ± 2.04 versus 2.79 ± 0.63, = 0.002, and 30.56 ± 8.11 versus 23.97 ± 7.8, = 0.031, resp.). In contrast, mean TAS and TOS levels were similar to baseline at all time points in Group II but IL-6 and IL-8 levels were increased at 2 (Group I-Group II, 16.84 ± 5.63 versus 44.81 ± 17.0, = 0.001, and 38.88 ± 9.8 versus 46.14 ± 9.25, = 0.038, resp.). . Even coated ECC systems are still incapable of attenuating the inflammatory response to cardiopulmonary bypass (CPB).