Shoji H, Ikeda N, Kojima C, Kitamura T, Suganuma H, Hisata K, Hirayama S, Ueno T, Miida T, Shimizu T
1Department of Pediatrics and Adolescent Medicine,Graduate School of Medicine,Juntendo University,Tokyo,Japan.
2Department of Pediatrics, Faculty of Medicine,Juntendo University,Tokyo,Japan.
J Dev Orig Health Dis. 2017 Apr;8(2):256-260. doi: 10.1017/S2040174416000684. Epub 2016 Dec 20.
Several studies have reported association of altered levels of lipids and some trace elements with risk factors for cardiovascular disease development in adulthood. Accordingly, the present study aimed to determine the relationship among the serum levels of copper (Cu), zinc (Zn), lipids, lipoproteins and apolipoproteins in preterm infants through an assessment of atherogenic indices shortly after birth. Blood samples were collected within 20 min of birth from 45 preterm infants with gestational ages ranging from 32 to 35 weeks. Serum Cu, Zn, total cholesterol (TC), low-density lipoprotein cholesterol (LDLc), high-density lipoprotein cholesterol (HDLc), apolipoprotein-A1 (apoA1) and apolipoprotein-B (apoB) levels were measured, and the TC/HDLc, LDLc/HDLc and apoB/apoA1 ratios were calculated. Upon determining the correlation between the levels of Cu, Zn and these indices of lipid metabolism, triglyceride (TG) and Cu were found to correlate negatively with birth weight (BW) and the standard deviation (s.d.) score for body weight. Furthermore, Cu levels correlated positively with the TG level and TC/HDLc, LDLc/HDLc and apoB/apoA1 ratios and negatively with the HDLc level and HDLc/apoA1 ratios. However, a stepwise multiple regression analysis indicated that the s.d. score for BW and TG level were significant independent determinants of the Cu level. In contrast, Zn did not correlate with any of these indices. In conclusion, intrauterine growth restriction and the TG level at birth influence Cu levels in preterm infants, whereas atherogenic indices do not affect this parameter.
多项研究报告称，脂质和一些微量元素水平的改变与成年人心血管疾病发生的危险因素相关。因此，本研究旨在通过评估出生后不久的致动脉粥样硬化指数，确定早产儿血清铜（Cu）、锌（Zn）、脂质、脂蛋白和载脂蛋白水平之间的关系。对45例胎龄在32至35周之间的早产儿在出生后20分钟内采集血样。检测血清Cu、Zn、总胆固醇（TC）、低密度脂蛋白胆固醇（LDLc）、高密度脂蛋白胆固醇（HDLc）、载脂蛋白A1（apoA1）和载脂蛋白B（apoB）水平，并计算TC/HDLc、LDLc/HDLc和apoB/apoA1比值。在确定Cu、Zn水平与这些脂质代谢指标之间的相关性时，发现甘油三酯（TG）和Cu与出生体重（BW）以及体重标准差（s.d.）评分呈负相关。此外，Cu水平与TG水平、TC/HDLc、LDLc/HDLc和apoB/apoA1比值呈正相关，与HDLc水平和HDLc/apoA1比值呈负相关。然而，逐步多元回归分析表明，BW的s.d.评分和TG水平是Cu水平的重要独立决定因素。相比之下，Zn与这些指标均无相关性。总之，宫内生长受限和出生时的TG水平影响早产儿的Cu水平，而致动脉粥样硬化指数不影响该参数。
