Kojima Chiharu, Shoji Hiromichi, Ikeda Naho, Kitamura Tomohiro, Hisata Ken, Shimizu Toshiaki
Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan.
Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Pediatr Int. 2017 Nov;59(11):1165-1168. doi: 10.1111/ped.13409. Epub 2017 Oct 24.
Given that preterm infants are born at a time of rapid fetal growth, they are at risk of deficiency of essential nutrients for brain development, including zinc (Zn) and copper (Cu). This study evaluate the relationship between serum Cu or Zn, gestational age (GA) and anthropometric parameters at birth in preterm infants.
This was a retrospective study of infants <35 weeks' GA from January 2010 to August 2012. We collected the data from medical records of 59 preterm infants at birth with regard to GA, anthropometric parameters, and serum Cu and Zn levels. Correlation of Cu, Zn, and GA with anthropometric parameters at birth was then done.
Zn was inversely correlated with GA, bodyweight (BW), body length (BL), and head circumference (HC), and Cu was inversely correlated with the standard deviation (SD) score for BW, BL, and HC. On stepwise multiple regression analysis, GA was a significant independent predictor of Zn level, and HC SD score was a significant independent predictor of Cu level.
Prematurity influences Zn, and intrauterine head growth restriction influences Cu at birth in preterm infants. Further research is needed to evaluate the relationship between intrauterine growth restriction and brain Cu metabolism.
鉴于早产儿出生时正处于胎儿快速生长阶段，他们有缺乏脑发育必需营养素的风险，包括锌（Zn）和铜（Cu）。本研究评估了早产儿血清铜或锌、胎龄（GA）与出生时人体测量参数之间的关系。
这是一项对2010年1月至2012年8月胎龄小于35周婴儿的回顾性研究。我们从59例早产儿出生时的病历中收集了关于胎龄、人体测量参数以及血清铜和锌水平的数据。然后对铜、锌和胎龄与出生时人体测量参数进行相关性分析。
锌与胎龄、体重（BW）、身长（BL）和头围（HC）呈负相关，铜与体重、身长和头围的标准差（SD）评分呈负相关。逐步多元回归分析显示，胎龄是锌水平的显著独立预测因素，头围标准差评分是铜水平的显著独立预测因素。
早产影响早产儿出生时的锌水平，宫内头部生长受限影响铜水平。需要进一步研究来评估宫内生长受限与脑铜代谢之间的关系。
