Xia Xiaojun, Duan Yun, Cui Jie, Jiang Junfeng, Lin Li, Peng Xiaojuan, Wang YuHong, Guo Bingtao, Liu Shouhai, Lei Xudong
a Department of Hematology , Tumor Hospital of Gansu Province , Lanzhou , Gansu , China.
b Department of Pharmacy , Tumor Hospital of Gansu Province , Lanzhou , Gansu , China.
Leuk Lymphoma. 2017 Aug;58(8):1887-1892. doi: 10.1080/10428194.2016.1265117. Epub 2016 Dec 20.
The aim of this study was to investigate the association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and additional gene-gene interaction with acute lymphoblastic leukemia (ALL) risk. Logistic regression was performed to investigate the association between two single nucleotide polymorphisms (SNPs) within MTHFR gene and ALL risk and additional gene-gene interaction between rs1801133 and rs1801131. The minor allele of rs1801133 and rs1801131 is associated with decreased ALL risk, OR (95% CI) were 0.61 (0.38-0.89), and 0.68 (0.50-0.96), respectively. We also found a significantly interaction between the two SNPs, participants with rs1801133 - CT or TT and rs1801131 - AC or CC genotype have the lowest ALL risk, compared with participants with rs1801133 - CC and rs1801131 - AA genotype, OR (95% CI) was 0.32 (0.12-0.63). We did not find any haplotype between the rs1801133 and rs1801131 associated with ALL risk. rs1801133 and rs1801131 within MTHFR gene and their interaction were both associated with ALL risk in Chinese children.
本研究旨在探讨亚甲基四氢叶酸还原酶（MTHFR）基因多态性及其他基因-基因相互作用与急性淋巴细胞白血病（ALL）风险的关联。采用逻辑回归分析来研究MTHFR基因内两个单核苷酸多态性（SNP）与ALL风险之间的关联，以及rs1801133和rs1801131之间的其他基因-基因相互作用。rs1801133和rs1801131的次要等位基因与ALL风险降低相关，其比值比（OR，95%可信区间）分别为0.61（0.38 - 0.89）和0.68（0.50 - 0.96）。我们还发现这两个SNP之间存在显著的相互作用，与rs1801133 - CC和rs1801131 - AA基因型的参与者相比，rs1801133 - CT或TT以及rs1801131 - AC或CC基因型的参与者ALL风险最低，OR（95%可信区间）为0.32（0.12 - 0.63）。我们未发现rs1801133和rs1801131之间存在与ALL风险相关的单倍型。MTHFR基因内的rs1801133和rs1801131及其相互作用均与中国儿童的ALL风险相关。
