Degtiareva E M, Ignatova M S
Ter Arkh. 1989;61(6):50-4.
The authors elucidate the role played by structural renal dysembryogenesis in the development, progress and outcome of nephropathies. Based on an analysis of mainly morphobiopsies of the kidneys in 298 patients aged 2.5 to 15 years a high incidence of renal dysembryogenesis is shown as an independent disease entity and as combined with acquired nephropathies. This provides basis for regarding structural deficiency of the kidneys as predisposing factor to the development of immune or microbial inflammation. The long-term (up to 18 years) observation over children with the most frequently occurring variant of renal dysembryogenesis, hypoplastic dysplasia, made it possible to define the main clinico-laboratory characteristics and outcome of the pathology determined by a high rate of the formation of chronic renal failure.
作者阐明了肾脏结构发育异常在肾病发生、发展及预后中所起的作用。基于对298例2.5至15岁患者主要肾脏形态活检的分析，结果显示肾脏发育异常作为一种独立的疾病实体以及与后天性肾病合并存在时的发病率很高。这为将肾脏结构缺陷视为免疫或微生物炎症发生的易感因素提供了依据。对最常见的肾脏发育异常类型——发育不全性发育异常患儿进行了长达18年的观察，从而得以确定由慢性肾衰竭高发生率所决定的该病理状况的主要临床实验室特征及预后。
