From the *Department of Nuclear Medicine, and †Institute of Pathology, Hannover Medical School, Hannover; and ‡Department of Anatomy and Experimental Morphology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Clin Nucl Med. 2017 Mar;42(3):e173-e174. doi: 10.1097/RLU.0000000000001487.
The prostate-specific membrane antigen (PSMA) is expressed by both prostate cancer and other neoplasms. We report the case of a 65-year-old man with castration-resistant metastatic prostate cancer who underwent Ga-PSMA ligand PET/CT for restaging of disease. Ga-PSMA ligand accumulation was noted in a thyroid lesion, suspicious for thyroid malignancy on complementary ultrasound. Subsequent resection and histopathological analysis showed follicular thyroid adenoma with PSMA expression in tumor neovasculature endothelial cells, but not in thyroid epithelial cells. It is important to be aware that both malignant and benign thyroid neoplasms may show PSMA expression to avoid misinterpretation.
前列腺特异性膜抗原（PSMA）在前列腺癌和其他肿瘤中均有表达。我们报告了一例 65 岁的去势抵抗性转移性前列腺癌患者，他接受 Ga-PSMA 配体 PET/CT 进行疾病再分期。Ga-PSMA 配体在甲状腺病变中蓄积，补充超声检查提示甲状腺恶性肿瘤可疑。随后的切除和组织病理学分析显示，肿瘤新生血管内皮细胞中有 PSMA 表达的滤泡状甲状腺腺瘤，但甲状腺上皮细胞中无 PSMA 表达。重要的是要意识到，恶性和良性甲状腺肿瘤都可能表现出 PSMA 表达，以避免误诊。
