Radner Helga, Lesperance Tamara, Accortt Neil A, Solomon Daniel H
Medical University of Vienna, Vienna, Austria.
DOCS Global, North Wales, Pennsylvania.
Arthritis Care Res (Hoboken). 2017 Oct;69(10):1510-1518. doi: 10.1002/acr.23171. Epub 2017 Sep 7.
To estimate prevalence and incidence of cardiovascular (CV) risk factors of hypertension, diabetes mellitus, hyperlipidemia, and obesity in patients with rheumatoid arthritis (RA), psoriasis, or psoriatic arthritis (PsA).
Patients with RA, psoriasis, or PsA were identified based on medical and pharmacy claims from the MarketScan claims databases from January 1, 2002 through December 31, 2014. Primary outcomes included age- and sex-standardized prevalence of CV risk factors during the 12 months preceding diagnosis date and incidence rates per 1,000 patient-years, with 95% confidence intervals (95% CIs) during followup.
Prevalence for RA, psoriasis, and PsA cohorts for hypertension was 18.6% (95% CI 18.3-18.8), 16.6% (95% CI 16.3-17.0), and 19.9% (95% CI 19.4-20.4), respectively; for diabetes mellitus 6.2% (95% CI 6.1-6.4), 6.3% (95% CI 6.0-6.5), and 7.8% (95% CI 7.4-8.2); for hyperlipidemia 9.9% (95% CI 9.7-10.1), 10.4% (95% CI 10.2-10.7), and 11.6% (95% CI 11.2-12.0); and for obesity 4.4% (95% CI 4.2-4.6), 3.8% (95% CI 3.5-4.0), and 6.0% (95% CI 5.6-6.5). Incidence rates per 1,000 patient-years during followup for RA, psoriasis, and PsA cohorts, respectively, for hypertension were 74.0 (95% CI 72.5-75.5), 68.2 (95% CI 65.9-70.4), and 79.8 (95% CI 76.3-83.3); for diabetes mellitus 10.6 (95% CI 10.1-11.1), 13.0 (95% CI 12.1-13.8), and 14.7 (95% CI 13.5-16.0); for hyperlipidemia 40.3 (95% CI 39.4-41.3), 47.1 (95% CI 45.4-48.7), and 52.0 (95% CI 49.6-54.3); and for obesity 24.4 (95% CI 23.4-25.4), 26.4 (95% CI 25.0-27.8), and 32.9 (95% CI 30.6-35.2).
Patients with RA, psoriasis, and PsA have high prevalence and incidence of CV risk factors, suggesting the need for risk factor monitoring of these patients.
评估类风湿关节炎（RA）、银屑病或银屑病关节炎（PsA）患者中高血压、糖尿病、高脂血症和肥胖等心血管（CV）危险因素的患病率和发病率。
根据2002年1月1日至2014年12月31日MarketScan理赔数据库中的医疗和药房理赔记录确定RA、银屑病或PsA患者。主要结局包括诊断日期前12个月内CV危险因素的年龄和性别标准化患病率以及每1000患者年的发病率，并在随访期间给出95%置信区间（95%CI）。
RA、银屑病和PsA队列中高血压的患病率分别为18.6%（95%CI 18.3 - 18.8）、16.6%（95%CI 16.3 - 17.0）和19.9%（95%CI 19.4 - 20.4）；糖尿病分别为6.2%（95%CI 6.1 - 6.4）、6.3%（95%CI 6.0 - 6.5）和7.8%（95%CI 7.4 - 8.2）；高脂血症分别为9.9%（95%CI 9.7 - 10.1）、10.4%（95%CI 10.2 - 10.7）和11.6%（95%CI 11.2 - 12.0）；肥胖分别为4.4%（95%CI 4.2 - 4.6）、3.8%（95%CI 3.5 - 4.0）和6.0%（95%CI 5.6 - 6.5）。RA、银屑病和PsA队列在随访期间每1000患者年高血压的发病率分别为74.0（95%CI 72.5 - 75.5）、68.2（95%CI 65.9 - 70.4）和79.8（95%CI 76.3 - 83.3）；糖尿病分别为10.6（95%CI 10.1 - 11.1）、13.0（95%CI 12.1 - 13.8）和14.7（95%CI 13.5 - 16.0）；高脂血症分别为40.3（95%CI 39.4 - 41.3）、47.1（95%CI 45.4 - 48.7）和52.0（95%CI 49.6 - 54.3）；肥胖分别为24.4（95%CI 23.4 - 25.4）、26.4（95%CI 25.0 -
