Aalberg J R, Hansen P
Ugeskr Laeger. 1989 Sep 18;151(38):2413-6.
Pigmented villonodular synovitis (PVS) is characterized by diffuse or localized proliferation of the synovial membrane in synovial joints, tendon sheaths or bursae. The etiology and pathogenesis are unknown. The condition is most frequently localized to the flexor tendon sheaths. Intraarticular PVS is most frequent in the knee joint. Swelling of the joint and slight pain develop. The localized intraarticular form may result in locking of the joint. The joint fluid is frequently haemorrhagic. The laboratory tests reveal normal findings. X-rays reveal erosion of the bone and cyst formation. Histological examination of the affected tissue is necessary to establish the diagnosis. Treatment consists of surgical excision. In the diffuse intraarticular form, this must take the form of total synovectomy. In cases with recurrence or pronounced destruction of bone, joint replacement may be indicated.
色素沉着绒毛结节性滑膜炎（PVS）的特征是滑膜关节、腱鞘或滑囊中滑膜的弥漫性或局限性增生。其病因和发病机制尚不清楚。该病最常局限于屈肌腱鞘。关节内PVS最常见于膝关节。会出现关节肿胀和轻微疼痛。局限性关节内型可能导致关节绞锁。关节液常为血性。实验室检查结果正常。X线显示骨质侵蚀和囊肿形成。必须对受影响组织进行组织学检查以确诊。治疗包括手术切除。对于弥漫性关节内型，必须进行全滑膜切除术。对于复发或骨质明显破坏的病例，可能需要进行关节置换。
