a Institute of Food Sciences, National Research Council , Avellino , Italy.
b Department of Pharmacognosy with Medicinal Plants Unit , Medical University of Lublin , Lublin , Poland.
Crit Rev Food Sci Nutr. 2018 May 24;58(8):1391-1405. doi: 10.1080/10408398.2016.1259983. Epub 2017 Jul 21.
In the past decades, extensive studies have reported the potential chemopreventive activity of sulforaphane, an isothiocyanate derived from glucoraphanin, occurring in large amounts in Brassica genus plants. Sulforaphane was found to be active against several forms of cancer. A growing body of data shows that sulforaphane acts against cancer at different levels, from development to progression, through pleiotropic effects. In this review, we discuss the available experimental and clinical data on the potential therapeutic role of sulforaphane against cancer. Its effects range from the protection of cells from DNA damage to the modulation of the cell cycle via pro-apoptotic, anti-angiogenesis and anti-metastasis activities. At molecular level, sulforaphane modulates cellular homeostasis via the activation of the transcription factor Nrf2. Although data from clinical studies are limited, sulforaphane remains a good candidate in the adjuvant therapy based on natural molecules against several types of cancer.
在过去几十年中，大量研究报告了萝卜硫素的潜在化学预防活性，萝卜硫素是一种异硫氰酸盐，大量存在于芸薹属植物中。萝卜硫素被发现对多种形式的癌症具有活性。越来越多的数据表明，萝卜硫素通过多效性作用在不同水平上对抗癌症，从发展到进展。在这篇综述中，我们讨论了萝卜硫素在癌症治疗方面的可用实验和临床数据。其作用范围从保护细胞免受 DNA 损伤到通过促凋亡、抗血管生成和抗转移活性来调节细胞周期。在分子水平上，萝卜硫素通过激活转录因子 Nrf2 来调节细胞内稳态。尽管来自临床研究的数据有限，但萝卜硫素仍然是基于天然分子对抗多种类型癌症的辅助治疗的一个很好的候选药物。
