老年胶质母细胞瘤：治疗模式与生存情况
Glioblastoma in the elderly: treatment patterns and survival.
作者信息
Pretanvil Jean-Aine, Salinas Isaac Q, Piccioni David E
机构信息
Department of Neurosciences, UCSD Moores Cancer Center, University of California San Diego, 3855 Health Science Drive, La Jolla, CA 92093-0819, USA.
出版信息
CNS Oncol. 2017 Jan;6(1):19-28. doi: 10.2217/cns-2016-0023. Epub 2016 Dec 21.
Abstract
AIM
The optimal treatment for elderly glioblastoma patients is unclear. We conducted a retrospective review of the California Cancer Registry to examine treatment patterns and survival by age.
METHODS
We identified 2670 adult patients from the California Cancer Registry with glioblastoma. We compared the extent of resection, treatment type and modality.
RESULTS
Elderly patients had the greatest overall survival (OS) with combined surgery, radiation and chemotherapy. However, they were more likely to undergo biopsy and less likely to receive combined radiation and chemotherapy than patients <70.
CONCLUSION
OS was maximized in elderly patients who were able to get some surgical resection and undergo combined radiation and chemotherapy. OS survival in some elderly patients may be improved by more extensive therapy.
摘要
目的
老年胶质母细胞瘤患者的最佳治疗方案尚不清楚。我们对加利福尼亚癌症登记处进行了一项回顾性研究，以按年龄检查治疗模式和生存率。
方法
我们从加利福尼亚癌症登记处识别出2670例成年胶质母细胞瘤患者。我们比较了切除范围、治疗类型和方式。
结果
老年患者接受手术、放疗和化疗联合治疗时总生存期（OS）最长。然而，与70岁以下患者相比，他们更有可能接受活检，而接受放疗和化疗联合治疗的可能性较小。
结论
能够进行一定程度手术切除并接受放疗和化疗联合治疗的老年患者的OS最大化。对一些老年患者进行更广泛的治疗可能会改善其OS生存率。
相似文献
1
Glioblastoma in the elderly: treatment patterns and survival.老年胶质母细胞瘤：治疗模式与生存情况
CNS Oncol. 2017 Jan;6(1):19-28. doi: 10.2217/cns-2016-0023. Epub 2016 Dec 21.
2
Survival and treatment patterns of glioblastoma in the elderly: a population-based study.老年人胶质母细胞瘤的生存和治疗模式：一项基于人群的研究。
World Neurosurg. 2012 Nov;78(5):518-26. doi: 10.1016/j.wneu.2011.12.008. Epub 2011 Dec 10.
3
Patterns of care and predictors of adjuvant therapies in elderly patients with glioblastoma: An analysis of the National Cancer Data Base.老年胶质母细胞瘤患者的治疗模式和辅助治疗的预测因素：国家癌症数据库分析。
Cancer. 2017 Sep 1;123(17):3277-3284. doi: 10.1002/cncr.30730. Epub 2017 Apr 27.
4
Outcomes and Patterns of Care in Elderly Patients with Glioblastoma Multiforme.老年多形性胶质母细胞瘤患者的结局和治疗模式。
World Neurosurg. 2021 May;149:e1026-e1037. doi: 10.1016/j.wneu.2021.01.028. Epub 2021 Jan 20.
5
The Prognostic Value of the Pretreatment Neutrophil/Lymphocyte Ratio in Patients with Glioblastoma Multiforme Brain Tumors: A Retrospective Cohort Study of Patients Treated with Combined Modality Surgery, Radiation Therapy, and Temozolomide Chemotherapy.多形性胶质母细胞瘤患者中性粒细胞/淋巴细胞比值的预后价值：联合治疗模式手术、放疗和替莫唑胺化疗治疗患者的回顾性队列研究。
Oncology. 2019;97(5):255-263. doi: 10.1159/000500926. Epub 2019 Jul 9.
6
Outcome of conventional treatment and prognostic factor in elderly glioblastoma patients.老年胶质母细胞瘤患者的传统治疗结果及预后因素
Acta Neurochir (Wien). 2014 Apr;156(4):641-51. doi: 10.1007/s00701-014-2020-1. Epub 2014 Feb 20.
7
Survival trends in elderly patients with glioblastoma multiforme: resective surgery, radiation, and chemotherapy.多形性胶质母细胞瘤老年患者的生存趋势：切除手术、放疗和化疗
Surg Neurol. 2004 Sep;62(3):207-13; discussion 214-5. doi: 10.1016/j.surneu.2003.11.016.
8
Treatment outcome of elderly patients with glioblastoma who received combination therapy.老年胶质母细胞瘤患者接受联合治疗的疗效。
Am J Clin Oncol. 2012 Oct;35(5):486-9. doi: 10.1097/COC.0b013e31821a82ae.
9
Patterns of care and survival in a retrospective analysis of 1059 patients with glioblastoma multiforme treated between 2002 and 2007: a multicenter study by the Central Nervous System Study Group of Airo (italian Association of Radiation Oncology).1059 例胶质母细胞瘤患者回顾性分析的治疗模式和生存结果：意大利放射肿瘤学协会 Airo 中枢神经系统研究组的多中心研究。
Neurosurgery. 2010 Aug;67(2):446-58. doi: 10.1227/01.NEU.0000371990.86656.E8.
10
Presentation, management, and outcome of newly diagnosed glioblastoma in elderly patients.新诊断的老年胶质母细胞瘤患者的临床表现、治疗及预后。
J Neurosurg. 2013 Apr;118(4):786-98. doi: 10.3171/2012.10.JNS112268. Epub 2012 Nov 23.
引用本文的文献
1
Resection versus biopsy in patients with glioblastoma (RESBIOP study): study protocol for an international multicentre prospective cohort study (ENCRAM 2202).切除与活检在胶质母细胞瘤患者中的对比（RESBIOP 研究）：一项国际多中心前瞻性队列研究（ENCRAM 2202）的研究方案。
BMJ Open. 2024 Sep 10;14(9):e081689. doi: 10.1136/bmjopen-2023-081689.
2
Baseline total brain volume predicts changes in quality of life and overall survival after cranial radiotherapy in older patients with glioblastoma: Results from the prospective BRITER study.基线全脑体积可预测老年胶质母细胞瘤患者头颅放疗后生活质量和总生存期的变化：前瞻性BRITER研究结果
Neurooncol Pract. 2024 Mar 9;11(4):413-420. doi: 10.1093/nop/npae019. eCollection 2024 Aug.
3
Treatment Strategies for Glioblastoma in the Elderly: What Should We Focus on Compared to Younger Patients.老年胶质母细胞瘤的治疗策略：与年轻患者相比，我们应关注什么。
Cancers (Basel). 2024 Mar 21;16(6):1231. doi: 10.3390/cancers16061231.
4
Characteristic analysis and identification of novel molecular biomarkers in elderly glioblastoma patients using the 2021 WHO Classification of Central Nervous System Tumors.利用2021年世界卫生组织中枢神经系统肿瘤分类对老年胶质母细胞瘤患者新型分子生物标志物进行特征分析与鉴定
Front Neurosci. 2023 Jun 9;17:1165823. doi: 10.3389/fnins.2023.1165823. eCollection 2023.
5
Newly Diagnosed Glioblastoma in Elderly Patients.老年新发胶质母细胞瘤。
Curr Oncol Rep. 2022 Mar;24(3):325-334. doi: 10.1007/s11912-022-01201-7. Epub 2022 Feb 5.
6
Treatment of Older Adult Patients with Glioblastoma: Moving towards the Inclusion of a Comprehensive Geriatric Assessment for Guiding Management.老年胶质母细胞瘤患者的治疗：走向纳入全面老年评估以指导管理。
Curr Oncol. 2022 Jan 14;29(1):360-376. doi: 10.3390/curroncol29010032.
7
Prognostic value of tumour volume in patients with a poor Karnofsky performance status scale - a bicentric retrospective study.卡氏功能状态评分差的患者肿瘤体积的预后价值 - 一项双中心回顾性研究。
BMC Neurol. 2021 Nov 15;21(1):446. doi: 10.1186/s12883-021-02424-0.
8
Treatment approach and survival from glioblastoma: results from a population-based retrospective cohort study from Western Norway.胶质母细胞瘤的治疗方法和生存结果：来自挪威西部基于人群的回顾性队列研究结果。
BMJ Open. 2021 Mar 12;11(3):e043208. doi: 10.1136/bmjopen-2020-043208.
9
Challenges and Perspectives of Standard Therapy and Drug Development in High-Grade Gliomas.高级别神经胶质瘤的标准治疗和药物研发的挑战与展望。
Molecules. 2021 Feb 22;26(4):1169. doi: 10.3390/molecules26041169.
10
Age-stratified clinical performance and survival of patients with IDH-wildtype glioblastoma homogeneously treated by radiotherapy with concomitant and maintenance temozolomide.IDH 野生型胶质母细胞瘤患者经同步和维持替莫唑胺放化疗的分层临床疗效和生存分析
J Cancer Res Clin Oncol. 2021 Jan;147(1):253-262. doi: 10.1007/s00432-020-03334-3. Epub 2020 Aug 3.
本文引用的文献
1
Survival in glioblastoma: a review on the impact of treatment modalities.胶质母细胞瘤的生存：关于治疗方式影响的综述
Clin Transl Oncol. 2016 Nov;18(11):1062-1071. doi: 10.1007/s12094-016-1497-x. Epub 2016 Mar 10.
2
Glioblastoma multiforme outcomes of 107 patients treated in two Singapore institutions.107例在新加坡两家机构接受治疗的多形性胶质母细胞瘤患者的治疗结果。
Singapore Med J. 2017 Jan;58(1):41-45. doi: 10.11622/smedj.2016044. Epub 2016 Feb 26.
3
A Surveillance, Epidemiology and End Results-Medicare data analysis of elderly patients with glioblastoma multiforme: Treatment patterns, outcomes and cost.一项对多形性胶质母细胞瘤老年患者的监测、流行病学和最终结果-医疗保险数据分析：治疗模式、结局和成本。
Mol Clin Oncol. 2015 Sep;3(5):971-978. doi: 10.3892/mco.2015.590. Epub 2015 Jun 26.
4
International Atomic Energy Agency Randomized Phase III Study of Radiation Therapy in Elderly and/or Frail Patients With Newly Diagnosed Glioblastoma Multiforme.国际原子能机构对新诊断为多形性胶质母细胞瘤的老年和/或体弱患者进行放射治疗的随机 III 期研究。
J Clin Oncol. 2015 Dec 10;33(35):4145-50. doi: 10.1200/JCO.2015.62.6606. Epub 2015 Sep 21.
5
Glioblastoma multiforme in the very elderly.
Neurosurg Rev. 2016 Jan;39(1):55-60; discussion 60-1. doi: 10.1007/s10143-015-0652-0. Epub 2015 Jul 26.
6
[Elderly patients with glioblastoma: state of the art].[老年胶质母细胞瘤患者：最新进展]
Bull Cancer. 2015 Mar;102(3):277-86. doi: 10.1016/j.bulcan.2015.02.002. Epub 2015 Feb 27.
7
Treatment options and outcomes for glioblastoma in the elderly patient.老年胶质母细胞瘤患者的治疗选择与预后
Clin Interv Aging. 2014 Feb 21;9:357-67. doi: 10.2147/CIA.S44259. eCollection 2014.
8
Glioblastoma therapy in the elderly: one age does not fit all.
Lancet Oncol. 2012 Sep;13(9):857-8. doi: 10.1016/S1470-2045(12)70368-6. Epub 2012 Aug 8.
9
Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial.替莫唑胺对比标准 6 周放疗对比低分割放疗用于 60 岁以上胶质母细胞瘤患者：北欧随机 3 期试验。
Lancet Oncol. 2012 Sep;13(9):916-26. doi: 10.1016/S1470-2045(12)70265-6. Epub 2012 Aug 8.
10
Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial.替莫唑胺化疗单独与单独放疗治疗老年恶性星形细胞瘤的比较：NOA-08 随机、3 期试验。
Lancet Oncol. 2012 Jul;13(7):707-15. doi: 10.1016/S1470-2045(12)70164-X. Epub 2012 May 10.
Zotero 插件