Pretanvil Jean-Aine, Salinas Isaac Q, Piccioni David E
Department of Neurosciences, UCSD Moores Cancer Center, University of California San Diego, 3855 Health Science Drive, La Jolla, CA 92093-0819, USA.
CNS Oncol. 2017 Jan;6(1):19-28. doi: 10.2217/cns-2016-0023. Epub 2016 Dec 21.
The optimal treatment for elderly glioblastoma patients is unclear. We conducted a retrospective review of the California Cancer Registry to examine treatment patterns and survival by age.
We identified 2670 adult patients from the California Cancer Registry with glioblastoma. We compared the extent of resection, treatment type and modality.
Elderly patients had the greatest overall survival (OS) with combined surgery, radiation and chemotherapy. However, they were more likely to undergo biopsy and less likely to receive combined radiation and chemotherapy than patients <70.
OS was maximized in elderly patients who were able to get some surgical resection and undergo combined radiation and chemotherapy. OS survival in some elderly patients may be improved by more extensive therapy.
老年胶质母细胞瘤患者的最佳治疗方案尚不清楚。我们对加利福尼亚癌症登记处进行了一项回顾性研究，以按年龄检查治疗模式和生存率。
我们从加利福尼亚癌症登记处识别出2670例成年胶质母细胞瘤患者。我们比较了切除范围、治疗类型和方式。
老年患者接受手术、放疗和化疗联合治疗时总生存期（OS）最长。然而，与70岁以下患者相比，他们更有可能接受活检，而接受放疗和化疗联合治疗的可能性较小。
能够进行一定程度手术切除并接受放疗和化疗联合治疗的老年患者的OS最大化。对一些老年患者进行更广泛的治疗可能会改善其OS生存率。
