Silva Paula Carolina Valença, Silva Aline Vieira da, Silva Taysa Nascimento, Vasconcelos Letícia Moura de, Gomes Adriana Vieira, Coêlho Maria Rosângela Cunha Duarte, Muniz Maria Tereza Cartaxo, Domingues Ana Lúcia Coutinho
Centro Acadêmico de Vitória, Universidade Federal de Pernambuco, Vitória de Santo Antão, Pernambuco, Brazil.
Laboratório de Biologia Molecular, Centro de Oncohematologia Pediátrica, Hospital Universitário Oswaldo Cruz, Universidade de Pernambuco, Recife, Pernambuco, Brazil.
Rev Soc Bras Med Trop. 2016 Nov-Dec;49(6):781-785. doi: 10.1590/0037-8682-0141-2016.
: We evaluated the associations between interleukin-10 (IL-10) gene polymorphisms -G1082A/-C819T/-C592A and periportal fibrosis regression after specific treatment for schistosomiasis.
: This retrospective cohort study involved 125 Brazilian patients infected with Schistosomiasis mansoni, who were followed up for 2 years after specific treatment to estimate the probability of periportal fibrosis regression.
: There was no evidence of associations between IL-10 polymorphisms and periportal fibrosis regression after treatment.
: There was no evidence of associations between gene promoter polymorphisms of IL-10 and the regression of periportal fibrosis in this Brazilian population.
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