甘露聚糖结合凝集素基因外显子 1（A/O）区多态性与特异性治疗后血吸虫病门脉周围纤维化消退的关系。
Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment.
机构信息
Universidade Federal de Pernambuco, Centro Acadêmico de Vitória, Vitória de Santo Antão, PE, Brasil.
Universidade de Pernambuco, Centro de Oncohematologia Pediátrica, Recife, PE, Brasil.
出版信息
Rev Soc Bras Med Trop. 2020 Dec 21;54:e01452020. doi: 10.1590/0037-8682-0145-2020. eCollection 2020.
INTRODUCTION
We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression.
METHODS
This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression.
RESULTS
A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression.
CONCLUSIONS
This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.
简介
我们评估了 MBL2 外显子 1（A/O 等位基因）和启动子区域-550（H/L 变体，rs11003125）和-221（X/Y 变体，rs7096206）的遗传多态性与门脉周围纤维化消退之间的关联。
方法
这是一项回顾性队列研究，涉及 114 名感染曼氏血吸虫的巴西人，他们在接受针对血吸虫病的特定治疗后进行了三年的随访，以估计门脉周围纤维化消退的概率。
结果
MBL2 外显子 1 的多态性与门脉周围纤维化消退之间存在风险关联。
结论
本研究提示 MBL2 外显子 1 的多态性可能有助于预测该人群的门脉周围纤维化消退。
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