安大略神经退行性疾病研究倡议（ONDRI）。

The Ontario Neurodegenerative Disease Research Initiative (ONDRI).

作者信息

Farhan Sali M K, Bartha Robert, Black Sandra E, Corbett Dale, Finger Elizabeth, Freedman Morris, Greenberg Barry, Grimes David A, Hegele Robert A, Hudson Chris, Kleinstiver Peter W, Lang Anthony E, Masellis Mario, McIlroy William E, McLaughlin Paula M, Montero-Odasso Manuel, Munoz David G, Munoz Douglas P, Strother Stephen, Swartz Richard H, Symons Sean, Tartaglia Maria Carmela, Zinman Lorne, Strong Michael J

机构信息

1Department of Biochemistry,Schulich School of Medicine & Dentistry,Western University,London,Canada.

2Robarts Research Institute,Western University,London,Canada.

出版信息

Can J Neurol Sci. 2017 Mar;44(2):196-202. doi: 10.1017/cjn.2016.415. Epub 2016 Dec 22.

DOI:10.1017/cjn.2016.415

PMID:28003035

Abstract

Because individuals develop dementia as a manifestation of neurodegenerative or neurovascular disorder, there is a need to develop reliable approaches to their identification. We are undertaking an observational study (Ontario Neurodegenerative Disease Research Initiative [ONDRI]) that includes genomics, neuroimaging, and assessments of cognition as well as language, speech, gait, retinal imaging, and eye tracking. Disorders studied include Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease, and vascular cognitive impairment. Data from ONDRI will be collected into the Brain-CODE database to facilitate correlative analysis. ONDRI will provide a repertoire of endophenotyped individuals that will be a unique, publicly available resource.

摘要

由于个体患痴呆症是神经退行性或神经血管性疾病的一种表现，因此需要开发可靠的方法来识别这些个体。我们正在进行一项观察性研究（安大略神经退行性疾病研究倡议[ONDRI]），该研究包括基因组学、神经影像学以及认知、语言、言语、步态、视网膜成像和眼动追踪评估。所研究的疾病包括阿尔茨海默病、肌萎缩侧索硬化症、额颞叶痴呆、帕金森病和血管性认知障碍。ONDRI的数据将被收集到Brain-CODE数据库中，以促进相关分析。ONDRI将提供一系列具有内表型特征的个体，这将是一个独特的、可供公众使用的资源。