安大略省神经退行性疾病研究倡议队列的特征。
Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort.
作者信息
Sunderland Kelly M, Beaton Derek, Arnott Stephen R, Kleinstiver Peter, Kwan Donna, Lawrence-Dewar Jane M, Ramirez Joel, Tan Brian, Bartha Robert, Black Sandra E, Borrie Michael, Brien Donald, Casaubon Leanne K, Coe Brian C, Cornish Benjamin, Dilliott Allison A, Dowlatshahi Dar, Finger Elizabeth, Fischer Corinne, Frank Andrew, Fraser Julia, Freedman Morris, Greenberg Barry, Grimes David A, Hassan Ayman, Hatch Wendy, Hegele Robert A, Hudson Christopher, Jog Mandar, Kumar Sanjeev, Lang Anthony, Levine Brian, Lou Wendy, Mandzia Jennifer, Marras Connie, McIlroy William, Montero-Odasso Manuel, Munoz David G, Munoz Douglas P, Orange Joseph B, Park David S, Pasternak Stephen H, Pieruccini-Faria Frederico, Rajji Tarek K, Roberts Angela C, Robinson John F, Rogaeva Ekaterina, Sahlas Demetrios J, Saposnik Gustavo, Scott Christopher J M, Seitz Dallas, Shoesmith Christen, Steeves Thomas D L, Strong Michael J, Strother Stephen C, Swartz Richard H, Symons Sean, Tang-Wai David F, Tartaglia Maria Carmela, Troyer Angela K, Turnbull John, Zinman Lorne, McLaughlin Paula M, Masellis Mario, Binns Malcolm A
机构信息
Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.
Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
出版信息
Alzheimers Dement. 2023 Jan;19(1):226-243. doi: 10.1002/alz.12632. Epub 2022 Mar 30.
INTRODUCTION
Understanding synergies between neurodegenerative and cerebrovascular pathologies that modify dementia presentation represents an important knowledge gap.
METHODS
This multi-site, longitudinal, observational cohort study recruited participants across prevalent neurodegenerative diseases and cerebrovascular disease and assessed participants comprehensively across modalities. We describe univariate and multivariate baseline features of the cohort and summarize recruitment, data collection, and curation processes.
RESULTS
We enrolled 520 participants across five neurodegenerative and cerebrovascular diseases. Median age was 69 years, median Montreal Cognitive Assessment score was 25, median independence in activities of daily living was 100% for basic and 93% for instrumental activities. Spousal study partners predominated; participants were often male, White, and more educated. Milder disease stages predominated, yet cohorts reflect clinical presentation.
DISCUSSION
Data will be shared with the global scientific community. Within-disease and disease-agnostic approaches are expected to identify markers of severity, progression, and therapy targets. Sampling characteristics also provide guidance for future study design.
引言
了解导致痴呆症表现改变的神经退行性病变与脑血管病变之间的协同作用，是一个重大的知识空白。
方法
这项多中心、纵向、观察性队列研究招募了患有常见神经退行性疾病和脑血管疾病的参与者，并对参与者进行了全面的多模式评估。我们描述了该队列的单变量和多变量基线特征，并总结了招募、数据收集和管理过程。
结果
我们招募了520名患有五种神经退行性疾病和脑血管疾病的参与者。年龄中位数为69岁，蒙特利尔认知评估分数中位数为25分，日常生活活动的基本独立性中位数为100%，工具性活动为93%。配偶研究伙伴占主导地位；参与者多为男性、白人且受教育程度较高。疾病较轻阶段占主导，但队列反映了临床表现。
讨论
数据将与全球科学界共享。疾病内和疾病无关的方法有望识别严重程度、进展的标志物以及治疗靶点。抽样特征也为未来的研究设计提供指导。
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