Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France.
J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1218-1225. doi: 10.1093/gerona/glw240.
Biological aging is characterized by a chronic low-grade inflammation level. This chronic phenomenon has been named "inflamm-aging" and is a highly significant risk factor for morbidity and mortality in the older persons. The most common theories of inflamm-aging include redox stress, mitochondrial dysfunction, glycation, deregulation of the immune system, hormonal changes, epigenetic modifications, and dysfunction telomere attrition. Inflamm-aging plays a role in the initiation and progression of age-related diseases such as type II diabetes, Alzheimer's disease, cardiovascular disease, frailty, sarcopenia, osteoporosis, and cancer. This review will cover the identification of pathways that control age-related inflammation across multiple systems and its potential causal role in contributing to adverse health outcomes.
生物老化的特征是慢性低度炎症水平。这种慢性现象被称为“炎症性老化”，是老年人发病率和死亡率的一个非常重要的危险因素。炎症性老化的最常见理论包括氧化应激、线粒体功能障碍、糖基化、免疫系统失调、激素变化、表观遗传修饰和端粒磨损功能障碍。炎症性老化在 2 型糖尿病、阿尔茨海默病、心血管疾病、虚弱、肌肉减少症、骨质疏松症和癌症等与年龄相关的疾病的发生和发展中起作用。这篇综述将涵盖识别控制多个系统与年龄相关炎症的途径及其在导致不良健康结果方面的潜在因果作用。
