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Idiopathic erythema multiforme: Evidence of underlying Janus kinase-signal transducer and activator of transcription activation and successful treatment with tofacitinib.

作者信息

Damsky William, King Brett A

机构信息

Department of Dermatology, Yale School of Medicine, New Haven, Connecticut.

出版信息

JAAD Case Rep. 2016 Dec 7;2(6):502-504. doi: 10.1016/j.jdcr.2016.10.009. eCollection 2016 Nov.

DOI:10.1016/j.jdcr.2016.10.009
PMID:28004029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5161778/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c0/5161778/105143c8b879/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c0/5161778/1bec9b286b8b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c0/5161778/105143c8b879/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c0/5161778/1bec9b286b8b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7c0/5161778/105143c8b879/gr2.jpg

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Idiopathic erythema multiforme: Evidence of underlying Janus kinase-signal transducer and activator of transcription activation and successful treatment with tofacitinib.特发性多形红斑：存在Janus激酶-信号转导及转录激活因子激活的潜在证据及托法替布治疗成功案例
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本文引用的文献

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Tofacitinib Citrate for the Treatment of Vitiligo: A Pathogenesis-Directed Therapy.枸橼酸托法替布治疗白癜风：一种针对发病机制的治疗方法。
JAMA Dermatol. 2015 Oct;151(10):1110-2. doi: 10.1001/jamadermatol.2015.1520.
2
Phenotype and genotype in 103 patients with tricho-rhino-phalangeal syndrome.103例毛发-鼻-指综合征患者的表型和基因型
Eur J Med Genet. 2015 May;58(5):279-92. doi: 10.1016/j.ejmg.2015.03.002. Epub 2015 Mar 16.
3
Use of ruxolitinib to successfully treat chronic mucocutaneous candidiasis caused by gain-of-function signal transducer and activator of transcription 1 (STAT1) mutation.
托法替尼抑制颗粒酶 B 阻断 CD8 T 细胞诱导的皮肤利什曼病病理。
J Invest Dermatol. 2021 Mar;141(3):575-585. doi: 10.1016/j.jid.2020.07.011. Epub 2020 Jul 30.
4
Current Perspectives on Erythema Multiforme.目前对多形红斑的认识。
Clin Rev Allergy Immunol. 2018 Feb;54(1):177-184. doi: 10.1007/s12016-017-8667-7.
5
JAK inhibition as a therapeutic strategy for immune and inflammatory diseases.JAK抑制作为免疫和炎症性疾病的一种治疗策略。
Nat Rev Drug Discov. 2017 Dec 28;17(1):78. doi: 10.1038/nrd.2017.267.
6
JAK inhibition as a therapeutic strategy for immune and inflammatory diseases.JAK 抑制作为治疗免疫和炎症性疾病的策略。
Nat Rev Drug Discov. 2017 Dec;16(12):843-862. doi: 10.1038/nrd.2017.201. Epub 2017 Nov 6.
7
JAK inhibitors in dermatology: The promise of a new drug class.皮肤科领域的JAK抑制剂：一类新药的前景
J Am Acad Dermatol. 2017 Apr;76(4):736-744. doi: 10.1016/j.jaad.2016.12.005. Epub 2017 Jan 28.
使用鲁索替尼成功治疗由功能获得性信号转导和转录激活因子1（STAT1）突变引起的慢性黏膜皮肤念珠菌病。
J Allergy Clin Immunol. 2015 Feb;135(2):551-3. doi: 10.1016/j.jaci.2014.12.1867.
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Remission of recalcitrant dermatomyositis treated with ruxolitinib.用鲁索替尼治疗顽固性皮肌炎的缓解情况。
N Engl J Med. 2014 Dec 25;371(26):2537-8. doi: 10.1056/NEJMc1412997.
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Killing two birds with one stone: oral tofacitinib reverses alopecia universalis in a patient with plaque psoriasis.一石二鸟：口服托法替布使一名斑块状银屑病患者的全秃症得到逆转。
J Invest Dermatol. 2014 Dec;134(12):2988-2990. doi: 10.1038/jid.2014.260. Epub 2014 Jun 18.
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A novel TRPS1 mutation in a family with tricho-rhino-phalangeal syndrome type 1.1型毛发-鼻-指综合征家族中的一种新型TRPS1突变。
J Dermatol. 2014 Jun;41(6):514-7. doi: 10.1111/1346-8138.12511.
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Trichorhinophalangeal syndrome with low expression of TRPS1 on epidermal and hair follicle epithelial cells.毛发-鼻-指（趾）综合征伴表皮和毛囊上皮细胞 TRPS1 低表达。
J Dermatol. 2013 May;40(5):396-8. doi: 10.1111/1346-8138.12111. Epub 2013 Mar 4.
8
Recurrent erythema multiforme: clinical characteristics, etiologic associations, and treatment in a series of 48 patients at Mayo Clinic, 2000 to 2007.复发性多形红斑：梅奥诊所 2000 年至 2007 年间 48 例患者的临床特征、病因学关联和治疗。
J Am Acad Dermatol. 2010 Jan;62(1):45-53. doi: 10.1016/j.jaad.2009.06.046. Epub 2009 Aug 7.
9
Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling.Trps1通过Stat3信号通路调节软骨细胞的增殖和凋亡。
Dev Biol. 2007 Dec 15;312(2):572-81. doi: 10.1016/j.ydbio.2007.10.001. Epub 2007 Oct 10.
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Expression of cytokines and chemokine receptors in the cutaneous lesions of erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis.细胞因子和趋化因子受体在多形红斑及史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症皮肤损伤中的表达
Br J Dermatol. 2006 Oct;155(4):722-8. doi: 10.1111/j.1365-2133.2006.07398.x.