• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

痴呆的影像学生物标志物:附有教学病例的推荐视觉评定量表

Imaging biomarkers of dementia: recommended visual rating scales with teaching cases.

作者信息

Wahlund Lars-Olof, Westman Eric, van Westen Danielle, Wallin Anders, Shams Sara, Cavallin Lena, Larsson Elna-Marie

机构信息

Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden.

Diagnostic Radiology, Clinical Sciences, Lund University, Lund, Sweden.

出版信息

Insights Imaging. 2017 Feb;8(1):79-90. doi: 10.1007/s13244-016-0521-6. Epub 2016 Dec 21.

DOI:10.1007/s13244-016-0521-6
PMID:28004274
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5265189/
Abstract

UNLABELLED

The diagnostic work up of dementia may benefit from structured reporting of CT and/or MRI and the use of standardised visual rating scales. We advocate a more widespread use of standardised scales as part of the workflow in clinical and research evaluation of dementia. We propose routine clinical use of rating scales for medial temporal atrophy (MTA), global cortical atrophy (GCA) and white matter hyperintensities (WMH). These scales can be used for evaluation of both CT and MRI and are efficient in routine imaging assessment in dementia, and may improve the accuracy of diagnosis. Our review provides detailed imaging examples of rating increments in each of these scales and a separate teaching file. The radiologist should relate visual ratings to the clinical assessment and other biomarkers to assist the clinician in the diagnostic decision.

TEACHING POINTS

• Clinical dementia diagnostics would benefit from structured radiological reporting. • Standardised rating scales should be used in dementia assessment. • It is important to relate imaging findings to the clinically suspected diagnosis.

摘要

未标注

痴呆的诊断检查可能受益于CT和/或MRI的结构化报告以及标准化视觉评定量表的使用。我们提倡更广泛地使用标准化量表,作为痴呆临床和研究评估工作流程的一部分。我们建议对内侧颞叶萎缩(MTA)、全脑皮质萎缩(GCA)和白质高信号(WMH)进行常规临床使用评定量表。这些量表可用于CT和MRI的评估,在痴呆的常规影像评估中效率高,且可能提高诊断准确性。我们的综述提供了这些量表中每个量表评分增加的详细影像示例以及一个单独的教学文件。放射科医生应将视觉评分与临床评估及其他生物标志物相关联,以协助临床医生做出诊断决策。

教学要点

• 临床痴呆诊断将受益于结构化放射学报告。• 标准化评定量表应用于痴呆评估。• 将影像结果与临床疑似诊断相关联很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72bc/5265189/dbaddc845cd0/13244_2016_521_Fig4a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72bc/5265189/e83346ccbd9b/13244_2016_521_Fig1a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72bc/5265189/6f935e6528eb/13244_2016_521_Fig2a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72bc/5265189/7d4dc116f0e5/13244_2016_521_Fig3a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72bc/5265189/dbaddc845cd0/13244_2016_521_Fig4a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72bc/5265189/e83346ccbd9b/13244_2016_521_Fig1a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72bc/5265189/6f935e6528eb/13244_2016_521_Fig2a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72bc/5265189/7d4dc116f0e5/13244_2016_521_Fig3a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72bc/5265189/dbaddc845cd0/13244_2016_521_Fig4a_HTML.jpg

相似文献

1
Imaging biomarkers of dementia: recommended visual rating scales with teaching cases.痴呆的影像学生物标志物:附有教学病例的推荐视觉评定量表
Insights Imaging. 2017 Feb;8(1):79-90. doi: 10.1007/s13244-016-0521-6. Epub 2016 Dec 21.
2
Automatically computed rating scales from MRI for patients with cognitive disorders.用于认知障碍患者的 MRI 自动计算评分量表。
Eur Radiol. 2019 Sep;29(9):4937-4947. doi: 10.1007/s00330-019-06067-1. Epub 2019 Feb 22.
3
Evaluation of MR Visual Rating Scales in Major Forms of Dementia.主要痴呆形式中磁共振成像视觉评分量表的评估
J Neurosci Rural Pract. 2021 Jan;12(1):16-23. doi: 10.1055/s-0040-1716806. Epub 2020 Nov 4.
4
Using visual rating to diagnose dementia: a critical evaluation of MRI atrophy scales.使用视觉评分诊断痴呆症:对 MRI 萎缩量表的批判性评估。
J Neurol Neurosurg Psychiatry. 2015 Nov;86(11):1225-33. doi: 10.1136/jnnp-2014-310090. Epub 2015 Apr 14.
5
Characteristics of Cortical Atrophy and White Matter Lesions Between Dementia With Lewy Bodies and Alzheimer's Disease: A Case-Control Study.路易体痴呆与阿尔茨海默病之间皮质萎缩和白质病变的特征:一项病例对照研究。
Front Neurol. 2022 Jan 11;12:779344. doi: 10.3389/fneur.2021.779344. eCollection 2021.
6
MRI Visual Ratings of Brain Atrophy and White Matter Hyperintensities across the Spectrum of Cognitive Decline Are Differently Affected by Age and Diagnosis.在认知衰退谱系中,脑萎缩和白质高信号的MRI视觉评分受年龄和诊断的影响不同。
Front Aging Neurosci. 2017 May 9;9:117. doi: 10.3389/fnagi.2017.00117. eCollection 2017.
7
The impact of MRI combined with visual rating scales on the clinical diagnosis of dementia: a prospective study.MRI联合视觉评定量表对痴呆临床诊断的影响:一项前瞻性研究。
Eur Radiol. 2016 Jun;26(6):1716-22. doi: 10.1007/s00330-015-3957-z. Epub 2015 Aug 29.
8
A new age-related cutoff of medial temporal atrophy scale on MRI improving the diagnostic accuracy of neurodegeneration due to Alzheimer's disease in a Chinese population.MRI 上与年龄相关的内侧颞叶萎缩量表新界值可提高中国人群阿尔茨海默病所致神经退行性变的诊断准确性。
BMC Geriatr. 2019 Feb 28;19(1):59. doi: 10.1186/s12877-019-1072-8.
9
MRI visual rating scales in the diagnosis of dementia: evaluation in 184 post-mortem confirmed cases.MRI视觉评定量表在痴呆诊断中的应用:184例尸检确诊病例的评估
Brain. 2016 Apr;139(Pt 4):1211-25. doi: 10.1093/brain/aww005. Epub 2016 Mar 1.
10
Reporting frequency of radiology findings increases after introducing visual rating scales in the primary care diagnostic work up of subjective and mild cognitive impairment.引入视觉评分量表后,初级保健中对主观和轻度认知障碍的诊断性检查中放射学发现的报告频率增加。
Eur Radiol. 2021 Feb;31(2):666-673. doi: 10.1007/s00330-020-07180-2. Epub 2020 Aug 26.

引用本文的文献

1
The Value of Structural Neuroimaging in First-Episode Psychosis and the Prevalence of Imaging Abnormalities and Clinical Relevance: A Real-World Observational Study.结构神经影像学在首发精神病中的价值、影像学异常的患病率及临床相关性:一项真实世界观察性研究
J Clin Med. 2025 Jul 11;14(14):4925. doi: 10.3390/jcm14144925.
2
A multimodal lifestyle intervention complemented with epigallocatechin gallate to prevent cognitive decline in APOE- ɛ4 carriers with Subjective Cognitive Decline: a randomized, double-blinded clinical trial (PENSA study).一项多模式生活方式干预联合表没食子儿茶素没食子酸酯预防主观认知衰退的 APOE-ɛ4 携带者认知衰退的随机双盲临床试验(PENSA 研究)。
J Prev Alzheimers Dis. 2025 Sep;12(8):100271. doi: 10.1016/j.tjpad.2025.100271. Epub 2025 Jul 15.
3

本文引用的文献

1
MRI visual rating scales in the diagnosis of dementia: evaluation in 184 post-mortem confirmed cases.MRI视觉评定量表在痴呆诊断中的应用:184例尸检确诊病例的评估
Brain. 2016 Apr;139(Pt 4):1211-25. doi: 10.1093/brain/aww005. Epub 2016 Mar 1.
2
Quantitative validation of a visual rating scale for frontal atrophy: associations with clinical status, APOE e4, CSF biomarkers and cognition.用于额部萎缩的视觉评分量表的定量验证:与临床状态、APOE e4、CSF 生物标志物和认知的关联。
Eur Radiol. 2016 Aug;26(8):2597-610. doi: 10.1007/s00330-015-4101-9. Epub 2015 Nov 11.
3
The Gothenburg MCI study: Design and distribution of Alzheimer's disease and subcortical vascular disease diagnoses from baseline to 6-year follow-up.
Assessment of Inter-Reader Reliability of Fazekas Scoring on Magnetic Resonance Imaging of the Brain in Adult Patients with Sickle Cell Disease.镰状细胞病成年患者脑部磁共振成像中 Fazekas 评分的阅片者间可靠性评估
Diagnostics (Basel). 2025 Mar 27;15(7):857. doi: 10.3390/diagnostics15070857.
4
Congruency between publicly available pictorial displays of medial temporal lobe atrophy.内侧颞叶萎缩的公开图片展示之间的一致性。
Eur Radiol. 2025 Apr 3. doi: 10.1007/s00330-025-11529-w.
5
Apathy in Dementia: A Pilot Study Providing Insights from Neuropsychiatric and Radiological Perspectives.痴呆症中的冷漠:一项从神经精神病学和放射学角度提供见解的初步研究。
J Clin Med. 2025 Mar 8;14(6):1822. doi: 10.3390/jcm14061822.
6
Brain Frailty on Neuroimaging Beyond Chronological Age Is Associated with Functional Outcome After Endovascular Thrombectomy in Patients with Anterior Large Vessel Occlusion.前循环大血管闭塞患者血管内血栓切除术后,神经影像显示的脑衰弱超越实际年龄与功能预后相关。
Ther Clin Risk Manag. 2025 Feb 18;21:149-159. doi: 10.2147/TCRM.S498094. eCollection 2025.
7
Brain MRI volumetry and atrophy rating scales as predictors of amyloid status and eligibility for anti-amyloid treatment in a real-world memory clinic setting.在现实世界的记忆诊所环境中,脑磁共振成像容积测定和萎缩评定量表作为淀粉样蛋白状态及抗淀粉样蛋白治疗资格的预测指标。
J Neurol. 2024 Dec 21;272(1):84. doi: 10.1007/s00415-024-12853-9.
8
Telehealth memory clinics in primary healthcare: real-world experiences from low-resource settings in Greece.初级医疗保健中的远程医疗记忆诊所:希腊资源匮乏地区的实际经验
Front Dement. 2024 Nov 27;3:1477242. doi: 10.3389/frdem.2024.1477242. eCollection 2024.
9
Daytime Sleepiness, Apnea, Neuroimaging Correlates and Cortisol Dysregulation in a Memory Clinic Cohort.日间嗜睡、睡眠呼吸暂停、神经影像学相关性与记忆门诊队列的皮质醇失调。
J Prev Alzheimers Dis. 2024;11(6):1798-1808. doi: 10.14283/jpad.2024.145.
10
Cerebrovascular and Alzheimer's disease biomarkers in dementia with Lewy bodies and other dementias.路易体痴呆和其他痴呆中的脑血管及阿尔茨海默病生物标志物
Brain Commun. 2024 Aug 28;6(5):fcae290. doi: 10.1093/braincomms/fcae290. eCollection 2024.
哥德堡轻度认知障碍研究:从基线到6年随访期内阿尔茨海默病和皮质下血管疾病诊断的设计与分布情况
J Cereb Blood Flow Metab. 2016 Jan;36(1):114-31. doi: 10.1038/jcbfm.2015.147.
4
Using visual rating to diagnose dementia: a critical evaluation of MRI atrophy scales.使用视觉评分诊断痴呆症:对 MRI 萎缩量表的批判性评估。
J Neurol Neurosurg Psychiatry. 2015 Nov;86(11):1225-33. doi: 10.1136/jnnp-2014-310090. Epub 2015 Apr 14.
5
Practical cut-offs for visual rating scales of medial temporal, frontal and posterior atrophy in Alzheimer's disease and mild cognitive impairment.阿尔茨海默病和轻度认知障碍患者内侧颞叶、额叶和后部萎缩的视觉评分量表的实用截断值。
J Intern Med. 2015 Sep;278(3):277-90. doi: 10.1111/joim.12358. Epub 2015 Apr 13.
6
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria.推进阿尔茨海默病研究诊断标准:IWG-2 标准。
Lancet Neurol. 2014 Jun;13(6):614-29. doi: 10.1016/S1474-4422(14)70090-0.
7
[Structural brain imaging may improve diagnostics in dementia].
Lakartidningen. 2013;110(47):2116-8.
8
Influence of age, disease onset and ApoE4 on visual medial temporal lobe atrophy cut-offs.年龄、发病年龄和 ApoE4 对视觉内侧颞叶萎缩截断值的影响。
J Intern Med. 2014 Mar;275(3):317-30. doi: 10.1111/joim.12148. Epub 2013 Oct 30.
9
The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies.路易体痴呆的患病率和发病率:人群和临床研究的系统评价。
Psychol Med. 2014 Mar;44(4):673-83. doi: 10.1017/S0033291713000494. Epub 2013 Mar 25.
10
Comparison between visual assessment of MTA and hippocampal volumes in an elderly, non-demented population.老年非痴呆人群中MTA视觉评估与海马体积的比较。
Acta Radiol. 2012 Jun 1;53(5):573-9. doi: 10.1258/ar.2012.110664. Epub 2012 May 16.