Smoryzanova O A, Proskuriakov S Ia, Dedenkov A N, Riabchenko N I
Vopr Onkol. 1989;35(8):967-70.
The paper discusses the effect of a cell differentiation-inducing agent--monomethylformamide--on the growth of ascites hepatoma 22A, Ehrlich ascites tumor, thymoma EL-4, leukemia L1210, Lewis lung carcinoma and hemocytoblastosis La. A single injection of the drug into tumor-bearing mice inhibited the growth of the said neoplasms as shown by cell levels in ascites tumors, node size of Lewis lung carcinoma and survival in animals with hemocytoblastosis La. The analysis of the kinetics of inhibition of growth to be transient. For both tumors, the effect of 0.25 g/kg body weight and more showed exponential growth.
本文讨论了一种细胞分化诱导剂——单甲基甲酰胺——对腹水型肝癌22A、艾氏腹水瘤、胸腺瘤EL-4、白血病L1210、刘易斯肺癌和血细胞增多症La生长的影响。将该药物单次注射到荷瘤小鼠体内，可抑制上述肿瘤的生长，这可通过腹水肿瘤中的细胞水平、刘易斯肺癌的结节大小以及血细胞增多症La动物的存活率来体现。生长抑制动力学分析表明这种抑制是短暂的。对于这两种肿瘤，体重0.25 g/kg及以上剂量的药物呈现指数增长效应。
