Department of Applied Physics, The Hong Kong Polytechnic University, Hong Kong, China.
Institute of Applied Physics and Computational Mathematics, Beijing, China.
Angew Chem Int Ed Engl. 2017 Jan 24;56(5):1283-1288. doi: 10.1002/anie.201607563. Epub 2016 Dec 22.
Detailed understanding of the interaction between a chiral molecule and a noble metal surface is essential to rationalize and advance interfacial self-assembly of amino acids and metal-mediated anchoring of proteins. Here we demonstrate that individual Au@Ag core-shell nanocuboids can serve as a plasmonic reporter of an extended helical network formed among chemisorbed cysteine molecules, through generating an interband absorption enhanced, Ag-surface-exclusive circular dichroism (CD) band in the UV region. The observed unusual, strong CD response in the hybrid Au@Ag-cysteine system can be used to probe in real time conformational evolution and structural rearrangement of biomolecules in general and also monitor the interfacial interaction between a metal surface and an adsorbed molecule, opening up the possibility of using Ag nanostructures as promising stereochemically attuned nanosensors.
详细了解手性分子与贵金属表面之间的相互作用，对于合理化和推进氨基酸的界面自组装以及蛋白质的金属介导固定至关重要。在这里，我们证明单个 Au@Ag 核壳纳米立方体形成为化学吸附半胱氨酸分子之间形成的扩展螺旋网络的等离子体报告器，通过在 UV 区域中产生增强的带间吸收，Ag 表面专有的圆二色性（CD）带。在混合的 Au@Ag-半胱氨酸体系中观察到的异常强的 CD 响应可用于实时探测生物分子的构象演变和结构重排，并且还可以监测金属表面和吸附分子之间的界面相互作用，为使用 Ag 纳米结构作为有前途的立体化学调谐纳米传感器开辟了可能性。
