前嗅核内侧部和腹侧海马对上嗅引导行为的自上而下调制。

Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.

Department of Psychology, University of Toronto, 100 St. George Street, Toronto, Ontario, Canada M5S 3G3.

Nat Commun. 2016 Dec 22;7:13721. doi: 10.1038/ncomms13721.

Olfactory processing is thought to be actively modulated by the top-down input from cortical regions, but the behavioural function of these signals remains unclear. Here we find that cortical feedback from the anterior olfactory nucleus pars medialis (mAON) bidirectionally modulates olfactory sensitivity and olfaction-dependent behaviours. To identify a limbic input that tunes this mAON switch, we further demonstrate that optogenetic stimulation of ventral hippocampal inputs to the mAON is sufficient to alter olfaction-dependent behaviours.

嗅觉加工被认为是由皮质区域的自上而下的输入主动调节的，但这些信号的行为功能尚不清楚。在这里，我们发现来自前嗅核中隔部（mAON）的皮质反馈双向调节嗅觉敏感性和嗅觉相关行为。为了确定调节该 mAON 开关的边缘输入，我们进一步证明，光遗传学刺激 mAON 的腹侧海马传入足以改变嗅觉相关行为。