Korotkov A G, Muzalevskaia D S, Kolokolov O V
Razumovskiy Saratov State Medical University, Saratov, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(9. Vyp. 2):44-48. doi: 10.17116/jnevro20161169244-48.
The article covers the pathogenesis of epilepsy and goals of modern pharmacotherapy. The features of the development of epilepsy of vascular origin are presented as well. The authors describe the ways to increase the efficacy and decrease side-effects of anticonvulsants (a combination with antioxidant and antihypoxant drugs that was confirmed by the data on an important role of free-radical processes in the pathogenesis of epilepsy). Mechanisms of action and efficacy of antioxidant treatment (on the example of 2-ethyl-6-methyl-3-hydroxypyridine succinate - mexidol) in the complex treatment of various forms of epilepsy are analyzed. The main advantages of mexidol as an add-on drug in the treatment of various types of epileptic syndrome in adults, taking into account its neuroprotective and antihypoxant action, are considered. Literature results have shown the positive effect of mexidol on the course of disease and its safety in the treatment of epilepsy.
本文涵盖了癫痫的发病机制和现代药物治疗的目标。还介绍了血管性癫痫的发展特点。作者描述了提高抗惊厥药疗效并降低其副作用的方法（与抗氧化剂和抗缺氧药物联合使用，自由基过程在癫痫发病机制中的重要作用的数据证实了这种联合用药的有效性）。分析了抗氧化治疗（以2-乙基-6-甲基-3-羟基吡啶琥珀酸盐——美西多为例子）在各种类型癫痫综合治疗中的作用机制和疗效。考虑到美西多的神经保护和抗缺氧作用，探讨了其作为附加药物在治疗成人各种类型癫痫综合征中的主要优势。文献结果表明美西多对癫痫病程有积极影响且治疗癫痫安全有效。
