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[1982年分离出的与猪流感病毒抗原相关的人类流感病毒研究]

[Study of human influenza viruses isolated in 1982 which are antigenically related to the swine flu virus].

作者信息

Iamnikova S S, Shemiakin I G, Nikolova Z, Kotseva R, Aĭmar M

出版信息

Vopr Virusol. 1989 May-Jun;34(3):288-92.

PMID:2800524
Abstract

Influenza A viruses (H1N1 serovariant) antigenically related to swine influenza viruses were isolated in March, 1982, from two sick adolescents in a rural area of Bulgaria who had had contacts with each other and with animals. The isolates, A/PRB/120/82 and A/PRB/121/82, were found to have hemagglutinin containing antigenic regions typical of hemagglutinin of both A/New Jersey/8/76 strain and A/swine/Finister/HG/82 strain. Because of the unusual structure of hemagglutinin, it is assumed that these viruses have not been introduced into Europe from the American continent. The limited nature of the outbreak is associated with the presence in virions of A/PRB/120/82 and A/PRB/121/82 strains of NP-protein typical of animal influenza viruses.

摘要

1982年3月,从保加利亚农村地区两名相互接触且与动物有接触的患病青少年身上分离出与猪流感病毒抗原相关的甲型流感病毒(H1N1血清变体)。分离出的毒株A/PRB/120/82和A/PRB/121/82,其血凝素含有A/新泽西/8/76毒株和A/猪/菲尼斯特雷/HG/82毒株血凝素典型的抗原区域。由于血凝素结构异常,推测这些病毒并非从美洲大陆传入欧洲。此次疫情范围有限与A/PRB/120/82和A/PRB/121/82毒株病毒粒子中存在动物流感病毒典型的核蛋白有关。

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