Pluhar W
Wien Klin Wochenschr. 1989 Sep 1;101(16):551-4.
A patient is described in whom treatment with the cholesterol-lowering agent Lovastatin (Mevacor MSD) led to a slight to moderate elevation of amylase and bilirubin with the occurrence of symptoms attributable to mild pancreatitis. These symptoms were sufficiently severe to require discontinuation of the drug. The concomitant existence of Gilbert's syndrome in this patient may have been causally related to the non-tolerance of this valuable drug. Although a penetrating ulcer cannot be ruled out in the differential diagnosis, the overall evidence favours the diagnosis of Lovastatin pancreatitis, a so far unpublished complication.
本文描述了一名患者，其使用降胆固醇药物洛伐他汀（美降之，默克雪兰诺公司生产）治疗后，淀粉酶和胆红素出现轻度至中度升高，并出现了可归因于轻度胰腺炎的症状。这些症状严重到足以要求停药。该患者同时存在吉尔伯特综合征，这可能与对这种有效药物不耐受存在因果关系。尽管在鉴别诊断中不能排除穿透性溃疡，但总体证据支持洛伐他汀性胰腺炎的诊断，这是一种迄今尚未发表的并发症。
