Harzendorf E, Müller E, Voigt H, Bomm M, Oddoy A, Merker G, Danzmann E
Klinik für Anästhesiologie und Intensivtherapie im Klinikum, Berlin-Buch, DDR.
Z Erkr Atmungsorgane. 1989;172(3):265-71.
Our investigations have demonstrated that the effect of oscillatory high-frequency ventilation (HFO) on gas exchange in dogs is directly proportional to the oscillatory flow amplitude VM. Because of the equation: VM = PM/Z, gas exchange is increasing with rising oscillatory amplitude of the ventilation pressure PM and decreasing with rising impedance Z of the respiratory system. This system consists of endotracheal tube and the lungs of the dog investigated. The impedance Z = square root of R2 + X2 (resistance R and reactance X) achieves a minimal value near at the resonant frequency (reactance X = 0, in healthy intubated dogs near at 5 Hz) and increases with rising oscillatory frequency. Thus the oscillatory high-frequency ventilation is most effective near to the resonant frequency of the respiratory system. The results presented allow the conclusion that the application of high-frequency ventilation can be optimized by monitoring the respiratory mechanics parameters.
我们的研究表明，振荡高频通气（HFO）对犬气体交换的影响与振荡流幅VM成正比。由于公式：VM = PM/Z，气体交换随着通气压力PM振荡幅度的增加而增加，随着呼吸系统阻抗Z的增加而降低。该系统由气管内导管和所研究犬的肺组成。阻抗Z = √(R² + X²)（电阻R和电抗X）在共振频率附近达到最小值（电抗X = 0，在健康插管犬中接近5Hz），并随着振荡频率的增加而增加。因此，振荡高频通气在接近呼吸系统共振频率时最有效。所呈现的结果表明，可以通过监测呼吸力学参数来优化高频通气的应用。
