Corral Juan E, Keihanian Tara, Kröner Paul T, Dauer Ryan, Lukens Frank J, Sussman Daniel A
a Division of Gastroenterology and Hepatology , Mayo Clinic , Jacksonville , FL , USA.
b Department of Medicine , University of Miami Miller School of Medicine - Jackson Memorial Hospital , Miami , FL , USA.
Scand J Gastroenterol. 2017 Apr;52(4):462-464. doi: 10.1080/00365521.2016.1267793. Epub 2016 Dec 22.
BACKGROUND/OBJECTIVE: Hiatal hernia is considered to be a predisposing factor to develop Mallory-Weiss Syndrome (MWS). No large case-control studies verifying this hypothesis have been conducted.
We reviewed all esophagogastroduodenoscopies with findings of MWS (n = 2342) in a national database and compared with age and gender-matched controls (n = 9368). Demographics, endoscopic characteristics and presence of a hiatal hernia were compared between both groups. Average age was 56.7 ± 18.6 years, and 72.4% were male.
Hiatal hernia was more common in controls, and no significant difference was seen in a multivariate analysis.
Dynamic changes inducing mucosal tension are more relevant determinants to develop MWS than gastro-esophageal junction location alone.
背景/目的：食管裂孔疝被认为是发生马洛里-魏斯综合征（MWS）的一个诱发因素。尚未有大型病例对照研究证实这一假说。
我们在一个国家数据库中回顾了所有发现有MWS的食管胃十二指肠镜检查病例（n = 2342），并与年龄和性别匹配的对照组（n = 9368）进行比较。比较了两组的人口统计学特征、内镜特征以及食管裂孔疝的存在情况。平均年龄为56.7±18.6岁，72.4%为男性。
食管裂孔疝在对照组中更常见，多因素分析未发现显著差异。
与单纯的胃食管交界处位置相比，引起黏膜张力的动态变化是发生MWS更相关的决定因素。
