Hong Shaodong, Zhang Li
Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, P. R. China.
Department of Medical Oncology, Sun Yat-sen University Cancer Cente, 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, P. R. China.
Chin J Cancer. 2016 Dec 22;35(1):100. doi: 10.1186/s40880-016-0163-6.
For decades, the selection of chemotherapeutic regimens for the treatment of recurrent or metastatic nasopharyngeal carcinoma has been mainly empirical. To our knowledge, there is no phase 3 trial that has been conducted to determine the optimal treatment for these patients before our publication. Recently, we published an article in The Lancet entitled "Gemcitabine plus cisplatin versus fluorouracil plus cisplatin in recurrent or metastatic nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial." The results of our study indicate that gemcitabine plus cisplatin could improve the survival of patients with recurrent or metastatic nasopharyngeal carcinoma compared with conventional fluorouracil plus cisplatin.
几十年来,复发性或转移性鼻咽癌化疗方案的选择主要基于经验。据我们所知,在我们发表这篇文章之前,尚无进行过的3期试验来确定这些患者的最佳治疗方案。最近,我们在《柳叶刀》杂志上发表了一篇题为《吉西他滨联合顺铂与氟尿嘧啶联合顺铂治疗复发性或转移性鼻咽癌:一项多中心、随机、开放标签的3期试验》的文章。我们的研究结果表明,与传统的氟尿嘧啶联合顺铂相比,吉西他滨联合顺铂可提高复发性或转移性鼻咽癌患者的生存率。