Miliutina N A, Karmanov P A, Krasiuk G K, Nekhliudova M Ia
Zh Obshch Biol. 1989 Jul-Aug;50(4):458-69.
The phenomenon of G2 phase prolongation was found in the population of mouse hepatocytes. In normal postnatal liver growth, G2 phase prolongation in not pronounced and occurs in a small fraction of proliferating hepatocytes. In case of liver regeneration after removal of 2/3 of the organ, G2 phase prolongation is observed in a population of hepatocytes, which response to the proliferative stimulus first. Estimation of individual variation in expression of prolonged G2 phase along with the detailed analysis of the structure of the process of proliferation in the main population of hepatocytes (cells with normal G2 phase) allows to define the biological meaning of the "G2-population" observed. The prolongation of G2 phase may result from non-specific cell damage in mitotic cycles, caused by destruction of trophic relations in liver during its growth and regeneration.
在小鼠肝细胞群体中发现了G2期延长的现象。在出生后肝脏的正常生长过程中，G2期延长并不明显，且仅发生在一小部分增殖的肝细胞中。在切除肝脏的三分之二后进行肝脏再生的情况下，在首先对增殖刺激作出反应的肝细胞群体中观察到了G2期延长。对延长的G2期表达的个体差异进行估计，并对主要肝细胞群体（G2期正常的细胞）增殖过程的结构进行详细分析，有助于确定所观察到的“G2群体”的生物学意义。G2期延长可能是由于肝脏生长和再生过程中营养关系的破坏导致有丝分裂周期中的非特异性细胞损伤所致。
