心脏手术中肝素与达那肝素抗体之间的交叉反应性
Cross-Reactivity Between Heparin and Danaparoid Antibodies in Cardiac Surgery.
作者信息
Ronchard Thibault, Salaun Erwan, Theron Alexis, Grisoli Dominique, Jaussaud Nicolas, Collart Frédéric, Habib Gilbert, Camoin-Jau Laurence
机构信息
Département Chirurgie Cardiaque, C.H.U. La Timone, APHM, Marseille, France.
Département Chirurgie Cardiaque, C.H.U. La Timone, APHM, Marseille, France; Service Cardiologie, C.H.U. La Timone, APHM, Marseille, France.
出版信息
Ann Thorac Surg. 2017 Jan;103(1):e9-e10. doi: 10.1016/j.athoracsur.2016.06.068.
Management of heparin-induced thrombocytopenia (HIT) entails cessation of heparin and initiation of a nonheparin parenteral anticoagulant such as danaparoid. Danaparoid cross-reactivity with HIT antibodies is an uncommon complication of treatment of HIT. We report the case of confirmed HIT and in vivo cross-reactivity with danaparoid, complicating severe sepsis due to an infectious endocarditis treated by cardiac surgery.
肝素诱导的血小板减少症（HIT）的管理需要停用肝素，并开始使用非肝素类胃肠外抗凝剂，如达那肝素。达那肝素与HIT抗体的交叉反应是HIT治疗中一种罕见的并发症。我们报告了一例确诊的HIT病例，该病例在体内与达那肝素发生交叉反应，使心脏手术治疗的感染性心内膜炎所致的严重脓毒症复杂化。
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