Hossain Md Jakir, Tanasescu Radu, Gran Bruno
Division of Clinical Neuroscience, University of Nottingham, School of Medicine, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom.
Division of Clinical Neuroscience, University of Nottingham, School of Medicine, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom; Department of Neurology, Neurosurgery and Psychiatry, University of Medicine and Pharmacy Carol Davila, Colentina Hospital, Bucharest, Romania.
J Neuroimmunol. 2017 Mar 15;304:11-20. doi: 10.1016/j.jneuroim.2016.12.004. Epub 2016 Dec 13.
Innate immunity relies on a set of germline-encoded receptors including Toll-like receptors (TLRs) that enable the host to discriminate between self and non-self. Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS). Infections are thought to play an important role in disease susceptibility. The role of innate immunity in MS has been recently appreciated. TLR2, a member of the TLR family, forms heterodimers with either TLR1 or TLR6 and detects a wide range of microbial as well as self-derived molecular structures. It may thus be important both in fighting infection and in activating autoimmunity. In this review, we discuss innate regulation of autoimmunity in MS with a focus on the role of TLR2 signaling.
固有免疫依赖于一组种系编码的受体，包括Toll样受体（TLR），这些受体使宿主能够区分自身和非自身。多发性硬化症（MS）是一种中枢神经系统（CNS）的自身免疫性炎性脱髓鞘疾病。感染被认为在疾病易感性中起重要作用。固有免疫在MS中的作用最近已得到重视。TLR2是TLR家族的成员，它与TLR1或TLR6形成异二聚体，并检测多种微生物以及自身来源的分子结构。因此，它在抵抗感染和激活自身免疫中可能都很重要。在这篇综述中，我们讨论MS中自身免疫的固有调节，重点是TLR2信号传导的作用。
