Komori Koji, Kinoshita Takashi, Taihei Oshiro, Ito Seiji, Abe Tetsuya, Senda Yoshiki, Misawa Kazunari, Ito Yuich, Uemura Norihisa, Natsume Seiji, Kawakami Jiro, Ouchi Akira, Tsutsuyama Masayuki, Hosoi Takahiro, Shigeyoshi Itaru, Akazawa Tomoyuki, Hayashi Daisuke, Tanaka Hideharu, Shimizu Yasuhiro
Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Nagoya J Med Sci. 2016 Dec;78(4):501-506. doi: 10.18999/nagjms.78.4.501.
We report a long-term survivor of colorectal cancer who underwent aggressive, frequent resection for peritoneal recurrences. A 58-year-old woman was diagnosed with descending colon cancer. Resection of the descending colon along with lymph node dissection was performed in September 2006. The pathological findings revealed Stage IIA colorectal cancer. The following peritoneal recurrences were removed: two in July 2007, two in the omental fat and two in the pouch of Douglas in June 2008 resected by low anterior resection of the rectum, one in the uterus and right ovarian recurrence resected via bilateral adnexectomy and Hartmann's procedure in May 2011, and one in the ascending colon by partial resection of the colon wall in December 2011. Postoperative adjuvant chemotherapy (uracil and tegafur/leucovorin, fluorouracil/levofolinate/oxaliplatin/bevacizumab, 5-fluorouracil/leucovorin/bevacizumab, irinotecan/bevacizumab, and irinotecan/panitumumab) was administered. The patient did not desire postoperative adjuvant chemotherapy after the fourth operation. The long-term survival was 6 years and 7 months.
我们报告了一名因腹膜复发而接受积极、频繁手术切除的结肠癌长期存活者。一名58岁女性被诊断为降结肠癌。2006年9月进行了降结肠切除术及淋巴结清扫术。病理结果显示为IIA期结肠癌。随后进行了多次腹膜复发灶切除:2007年7月切除2处,2008年6月通过直肠低位前切除术切除网膜脂肪处2处及Douglas窝处2处,2011年5月通过双侧附件切除术及Hartmann手术切除子宫及右卵巢复发灶1处,2011年12月通过部分结肠壁切除术切除升结肠处1处。术后给予辅助化疗(尿嘧啶和替加氟/亚叶酸钙、氟尿嘧啶/亚叶酸钙/奥沙利铂/贝伐单抗、5-氟尿嘧啶/亚叶酸钙/贝伐单抗、伊立替康/贝伐单抗以及伊立替康/帕尼单抗)。在第四次手术后,患者拒绝接受术后辅助化疗。患者长期存活达6年7个月。