低剂量丙戊酸改善非24小时睡眠-觉醒综合征：一例报告
Non-24-hour sleep-wake syndrome improved by low-dose valproic acid: a case report.
作者信息
Kurita Masatake, Moriya Takahiro, Nishino Satoshi, Hirata Eishin, Hirasawa Noriyasu, Okubo Yoshiro, Sato Tadahiro
机构信息
Wakamiya Hospital, Koutokukai, Yoshihara, Yamagata; Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi; Department of Psychiatry and Behavioral Science, Graduate School of Medicine, Nippon Medical School, Sendagi, Tokyo.
Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi.
出版信息
Neuropsychiatr Dis Treat. 2016 Dec 13;12:3199-3203. doi: 10.2147/NDT.S115648. eCollection 2016.
A woman was diagnosed with non-24-hour sleep-wake syndrome and depressive symptoms. Her depressive symptoms did not respond to standard doses of several antidepressants or mood stabilizers. Furthermore, her sleep-wake cycle remained non-entrained despite treatment with a melatonin-related drug, vitamin B12, and phototherapy. Ultimately, her sleep-wake rhythm was restored to a 24-hour pattern with a low dose of valproic acid, and her depressive symptoms tended to improve as a result of synchronization without antidepressants. Low-dose valproic acid appears to be one of the effective means of entraining circadian rhythms in patients with non-24-hour sleep-wake syndrome, which in turn likely improves associated depressive symptoms.
一名女性被诊断患有非24小时睡眠-觉醒综合征及抑郁症状。她的抑郁症状对几种抗抑郁药或心境稳定剂的标准剂量均无反应。此外，尽管使用了褪黑素相关药物、维生素B12和光疗进行治疗，她的睡眠-觉醒周期仍未调整。最终，低剂量丙戊酸使她的睡眠-觉醒节律恢复为24小时模式，并且在未使用抗抑郁药的情况下，由于节律同步，她的抑郁症状趋于改善。低剂量丙戊酸似乎是使非24小时睡眠-觉醒综合征患者昼夜节律同步的有效方法之一，这反过来可能改善相关的抑郁症状。
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