Kohsaka M
Sapporo Hanazono Hospital.
Nihon Rinsho. 1998 Feb;56(2):410-5.
The sleep-wake cycle in non-24-hour sleep-wake syndrome is longer than 24 hours. Patients go to bed a little bit later each day and then can not fall asleep and wake up at the usual time. The same sleep patterns and free running rhythms in healthy subjects have been seen in temporal isolation. The mechanism of this syndrome has not been clarified, but several factors have been proposed as follows: 1) the weakness of Zeitgeber 2) decrease of sensitivity to Zeitgeber 3) the period of the circadian system is much longer than 24 hours. Vitamin B12 and melatonin were reported to be effective in treating this syndrome.
非24小时睡眠-清醒综合征的睡眠-清醒周期长于24小时。患者每天上床睡觉的时间会稍晚一些，然后无法入睡，且会在通常时间醒来。在时间隔离状态下，健康受试者也出现过相同的睡眠模式和自由运行节律。该综合征的发病机制尚未阐明，但已提出以下几个因素：1）时间线索的减弱；2）对时间线索敏感性的降低；3）昼夜节律系统的周期远长于24小时。据报道，维生素B12和褪黑素对治疗该综合征有效。
