术前慢性肾衰竭对肝移植的影响：一项基于人群的队列研究。
Impact of preoperative chronic renal failure on liver transplantation: a population-based cohort study.
作者信息
Chung Peter Chi-Ho, Chen Hsiu-Pin, Lin Jr-Rung, Liu Fu-Chao, Yu Huang-Ping
机构信息
Department of Anesthesiology, Chang Gung Memorial Hospital; College of Medicine.
Clinical Informatics and Medical Statistics Research Center; Graduate Institute of Clinical Medicine, Chang Gung University, Taoyuan, Taiwan.
出版信息
Ther Clin Risk Manag. 2016 Dec 14;12:1855-1860. doi: 10.2147/TCRM.S123011. eCollection 2016.
PURPOSE
The purpose of this study was to assess whether preoperative chronic renal failure (CRF) affects the rates of postoperative complications and survival after liver transplantation.
METHODS
This population-based retrospective cohort study included 2,931 recipients of liver transplantation performed between 1998 and 2012, enrolled from the Taiwan National Health Insurance Research Database. Patients were divided into two groups, based on the presence or absence of preoperative CRF.
RESULTS
The overall estimated survival rate of liver transplantation recipients (LTRs) with preoperative CRF was significantly lower than that of patients without preoperative CRF (=0.0085). There was no significant difference between the groups in terms of duration of intensive care unit stay, total hospital stay, bacteremia, postoperative bleeding, and pneumonia during hospitalization. Long-term adverse effects, including cerebrovascular disease and coronary heart disease, were not different between patients with versus without CRF.
CONCLUSION
These findings suggest that LTRs with preoperative CRF have a higher rate of mortality.
目的
本研究旨在评估术前慢性肾衰竭（CRF）是否会影响肝移植术后的并发症发生率及生存率。
方法
这项基于人群的回顾性队列研究纳入了1998年至2012年间在台湾国民健康保险研究数据库登记的2931例肝移植受者。根据术前是否存在CRF将患者分为两组。
结果
术前患有CRF的肝移植受者（LTRs）的总体估计生存率显著低于术前未患CRF的患者（P = 0.0085）。两组在重症监护病房住院时间、总住院时间、菌血症、术后出血及住院期间肺炎方面无显著差异。包括脑血管疾病和冠心病在内的长期不良反应在有CRF和无CRF的患者之间并无差异。
结论
这些发现表明，术前患有CRF的LTRs死亡率更高。
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